P. Saftig

MFSD1 in complex with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes

The paper identifies MFSD1 as a lysosomal dipeptide uniporter that facilitates the transport of cationic and neutral dipeptides when amino acid exporters are overloaded.

Tspan15 depletion in mice affects social investigation and aggressive behavior

This study shows that Tspan15 depletion in mice increases social investigation and aggression, suggesting a role in neuronal circuits controlling aggressive behavior.

Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages

This study shows that Lamin A/C protects lung alveolar macrophages from nuclear envelope rupture and aging-related DNA damage, linking NE disruption to genomic instability and senescence.

Lysosome-targeted lipid probes reveal sterol transporters NPC1 and LIMP2 as sphingosine transporters

The paper develops lipid probes to study sphingosine transport, revealing NPC1 and LIMP2 as sphingosine transporters and showing their role in cholesterol efflux.

LAMP3 is critical for surfactant homeostasis in mice

This study shows that LAMP3 is essential for maintaining pulmonary surfactant homeostasis in mice, as its absence leads to altered surfactant composition and lung function.

Tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex

The paper identifies Tspan15 as a critical partner of ADAM10, showing their interaction and functional synergy in proteolytic activity.