S. H. Chan

The paper identifies MFSD1 as a lysosomal dipeptide uniporter that facilitates the transport of cationic and neutral dipeptides when amino acid exporters are overloaded.

This paper describes an RNA capping enzyme-T7 RNA polymerase fusion protein that efficiently generates capped synthetic mRNA in a one-step process, achieving up to 95% Cap-1 incorporation.

This paper demonstrates a solid-phase enzymatic platform for streamlined mRNA synthesis, enabling efficient and continuous production of capped RNA without purification steps.

This study characterizes a single-subunit RNA capping enzyme from Faustovirus, showing it efficiently generates Cap-0 structures and has advantageous properties for synthetic mRNA manufacturing.

This study shows that protein condensates and lipid domains couple to organize T-cell membrane function during activation.

The paper screens compounds targeting metabolism in serum-derived medium to identify differential responses in cancer cells, aiming to improve drug response prediction.

The paper identifies MCART1 as a mitochondrial NAD+ transporter in human cells by showing its essentiality with ETC components and its effect on NAD levels and mitochondrial function.

This study identifies dihydroxyacetone phosphate (DHAP) as the glucose-derived metabolite that activates mTORC1, linking glucose availability to cell growth regulation.

The paper quantifies microenvironmental metabolites in murine cancer models and identifies factors affecting tumor nutrient availability.