Monocytes use protrusive forces to generate migration paths in viscoelastic collagen-based extracellular matrices
K. Adebowale, C. J. Allan, B. Ha, A. Saraswathibhatla, J. Zhu, D. Indana, M. Popescu, S. Demirdjian, H. A. Martinez, A. Esclamado, J. Yang, M. C. Bassik, C. Franck, P. Bollyky, O. Chaudhuri
This study shows that monocytes migrate through viscoelastic collagen matrices by generating protrusive forces via actin polymerization, with increased matrix stiffness and viscoelasticity enhancing their 3D migration.
bioRxiv · Jun 9, 2023Cell Biology