C. Franck

Cortical spheroids show strain-dependent cell viability loss and neurite disruption following sustained compression injury

The paper presents an in vitro model of sustained compressive neural injury using cortical spheroids and shows increased DNA damage and microtubule degradation under higher compressive strain.

Monocytes use protrusive forces to generate migration paths in viscoelastic collagen-based extracellular matrices

This study shows that monocytes migrate through viscoelastic collagen matrices by generating protrusive forces via actin polymerization, with increased matrix stiffness and viscoelasticity enhancing their 3D migration.

Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins

The paper discovers and characterizes cyclic peptides that selectively bind to the C-terminal bromodomains of BET family proteins, showing high potency and paralogue-specificity.

A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein

This paper discovers a macrocyclic peptide that inhibits SARS-CoV-2 and related sarbecoviruses by targeting a conserved site in the spike protein, offering a potential broad-spectrum antiviral.

Discovery of Cyclic Peptide Ligands to the SARS-CoV-2 Spike Protein using mRNA Display

The paper identifies cyclic peptide ligands to the SARS-CoV-2 spike protein RBD using mRNA display, finding six high-affinity molecules with nanomolar dissociation constants.

Neural cell injury pathology due to high-rate mechanical loading

The paper quantifies neural cell injury thresholds under high-rate mechanical loading using a 3D in vitro model and inertial microcavitation rheology, revealing distinct physical injury mechanisms.

Breast tumor stiffness instructs bone metastasis via mechanical memory

This study shows that primary tumor stiffness induces stable mechanical memory in breast cancer cells, promoting bone metastasis through ERK-RUNX2 signaling and a MeCo score.

Context-dependent role of vinculin in neutrophil adhesion, motility and trafficking

This study investigates the role of vinculin in neutrophil adhesion, motility, and trafficking, finding that it partially affects adhesion and spreading but is dispensable for recruitment in vivo.

Mechanophenotyping of 3D Multicellular Clusters using Displacement Arrays of Rendered Tractions

The paper develops a method to measure multicellular tractions in 3D biomaterials using displacement arrays, revealing changes in traction patterns during epithelial-mesenchymal transition and drug perturbations.

CHD4 slides nucleosomes by decoupling entry- and exit-side DNA translocation

This study investigates the mechanism of CHD4-mediated nucleosome sliding using single-molecule assays, revealing a decoupling of DNA translocation at entry and exit sides.

A simple linearization method unveils hidden enzymatic assay interferences

This paper introduces a linearization method to detect hidden enzymatic assay interferences by analyzing progress curves in modified coordinates, improving the accuracy of kinetic data selection.