Author

O. Chaudhuri

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Research Focus:development & morphogenesis· 2 Organism:mouse· 2 Organism:Drosophila· 1 Assay:imaging· 1

Frequent Co-Authors

A. Saraswathibhatla· 2 shared J. Chang· 2 shared M. C. Bassik· 2 shared R. B. West· 2 shared S. Nam· 2 shared S. Varma· 2 shared A. A. Dominguez· 1 shared A. C. Martin· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

A. Saraswathibhatla

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Author profile →

6 papers

Recent·Most cited

Stress relaxing granular bioprinting materials enable complex and uniform organoid self-organization

A. J. Graham, M. W. L. Khoo, V. Srivastava, S. Viragova, H. Kim, K. Parekh, K. M. Hennick, M. Bird, N. Goldhammer, J. Z. Yu, G. Hu, N. T. Brinkley, L. Pardo, J. S. Amaya, C. D. Morley, , Z. J. Gartner

This paper introduces a tunable granular biomaterial, MAGIC matrix, that enables precise control of initial conditions for tissue growth, leading to improved organoid reproducibility and complexity.

bioRxiv · Feb 1, 2024Bioengineering

Monocytes use protrusive forces to generate migration paths in viscoelastic collagen-based extracellular matrices

K. Adebowale, C. J. Allan, B. Ha, A. Saraswathibhatla, J. Zhu, D. Indana, M. Popescu, S. Demirdjian, H. A. Martinez, A. Esclamado, J. Yang, M. C. Bassik, C. Franck, P. Bollyky, O. Chaudhuri

This study shows that monocytes migrate through viscoelastic collagen matrices by generating protrusive forces via actin polymerization, with increased matrix stiffness and viscoelasticity enhancing their 3D migration.

bioRxiv · Jun 9, 2023Cell Biology

Collective invasion of the basement membrane in breast cancer driven by forces from cell volume expansion and local contractility

J. Chang, A. Saraswathibhatla, Z. Song, S. Varma, C. Sanchez, S. Srivastava, K. Liu, M. C. Bassik, M. P. Marinkovich, L. Hodgson, V. Shenoy, R. B. West, O. Chaudhuri

This study shows breast cancer cells invade the basement membrane using both proteases and mechanical forces from cell volume expansion and local contractility.

bioRxiv · Jul 28, 2022 · PreprintCancer Biology

Delivery of CAR-T Cells in a Transient Injectable Stimulatory Hydrogel Niche Improves Treatment of Solid Tumors

A. K. Grosskopf, L. Labanieh, D. D. Klysz, G. Roth, P. Xu, O. Adebowale, E. C. G. C. Gale, C. K. Jons, J. H. Klich, J. Yan, C. L. Maikawa, S. Correa, B. S. Ou, A. I. d'Aquino, J. R. Cochran, , E. Appel

This paper develops an injectable hydrogel to co-deliver CAR-T cells and cytokines, enhancing solid tumor treatment in mice by creating a transient inflammatory niche.

bioRxiv · Dec 20, 2021Bioengineering

The nature of mitotic forces in epithelial monolayers

V. K. Gupta, S. Nam, J. Camuglia, J. L. Martin, E. N. Sanders, L. E. O'Brien, A. C. Martin, T. Kim, O. Chaudhuri

This study identifies two distinct stages of mitotic force generation in epithelial monolayers: protrusive forces driving mitotic elongation and outward forces facilitating post-mitotic re-spreading.

bioRxiv · Nov 16, 2020Cell Biology

YAP-independent mechanotransduction drives breast cancer progression

J. Y. Lee, J. Chang, A. A. Dominguez, S. Nam, J. Chang, H.-p. Lee, S. Varma, L. S. Qi, R. B. West, O. Chaudhuri

This study shows that mechanotransduction in breast cancer occurs without YAP, due to compact nuclear morphologies in vivo.

bioRxiv · Dec 13, 2018Cancer Biology