P. Bollyky

The contribution of neutrophils to bacteriophage clearance and pharmacokinetics in vivo

This study examines how neutrophils affect bacteriophage clearance and pharmacokinetics in mice, finding minimal impact from neutrophils but significant inactivation of phages over time.

Monocytes use protrusive forces to generate migration paths in viscoelastic collagen-based extracellular matrices

This study shows that monocytes migrate through viscoelastic collagen matrices by generating protrusive forces via actin polymerization, with increased matrix stiffness and viscoelasticity enhancing their 3D migration.

Inhibition of hyaluronan synthesis prevents β-cell loss in obesity-associated type 2 diabetes

This study shows that inhibiting hyaluronan synthesis with 4-MU prevents β-cell loss in obesity-associated type 2 diabetes by increasing survivin expression and blocking apoptosis.

A filamentous phage triggers antiviral responses in cystic fibrosis basal airway epithelial cells

This study investigates how cystic fibrosis basal airway epithelial cells respond to the filamentous phage Pf4 and LPS, showing antiviral responses and altered immune signaling.

The pharmacokinetics and pharmacodynamics of 4-methylumbelliferone and its glucuronide metabolite in mice

This paper investigates the pharmacokinetics and pharmacodynamics of 4-MU and its metabolite 4-MUG in mice, showing significant differences in exposure and bioavailability between administration routes.

The circulating phageome reflects bacterial infections

The paper shows that circulating phageome in cfDNA reflects bacterial infections and can distinguish between pathogenic and contaminant bacteria.

Methods for Extraction and Detection of Bacteriophage DNA from the Sputum of Patients with Cystic Fibrosis

This paper evaluates and optimizes methods for extracting bacteriophage DNA from CF patient sputum to improve detection of both bacteria and bacteriophage.

Sustained Release of IL-2 Using an Injectable Hydrogel Prevents Autoimmune Diabetes

This paper develops an IL-2 hydrogel that prevents diabetes in NOD mice by sustained release and immune modulation.