Mice with renal-specific alterations of stem cell-associated signaling develop symptoms of chronic kidney disease but surprisingly no tumors
A. Myszczyszyn, O. Popp, S. Kunz, A. Sporbert, S. Jung, L. C. Penning, A. Fendler, P. Mertins, W. Birchmeier
The paper generates kidney organoids and genetic mouse models with altered stem cell signaling, finding CKD symptoms but no tumors.
bioRxiv · Feb 28, 2023Cell Biology