S. Kunz

finsyncR, an R package to synchronize 27 years of fish and invertebrate data across the United States

finsyncR simplifies access to and integration of 27 years of fish and macroinvertebrate data from US streams and rivers, providing cleaned datasets and tools to address common data challenges.

Structure of hepatitis B/D antiviral drug Bulevirtide bound to its receptor protein NTCP

The paper determines the cryo-EM structure of bulevirtide bound to NTCP, revealing its mechanism of inhibiting HBV/HDV entry and providing insights for drug development.

Mice with renal-specific alterations of stem cell-associated signaling develop symptoms of chronic kidney disease but surprisingly no tumors

The paper generates kidney organoids and genetic mouse models with altered stem cell signaling, finding CKD symptoms but no tumors.

Amplicon structure creates collateral therapeutic vulnerability in cancer

The paper identifies DDX1 as a passenger gene co-amplified with MYCN in cancer, showing that its aberrant expression creates a therapeutic vulnerability through mTORC1 dependency.

Structural insights into crista junction formation by the Mic60-Mic19 complex

This study reveals the structural role of the Mic60-Mic19 complex in forming mitochondrial crista junctions by acting as a molecular strut that controls their architecture.

A ganglioside-based senescence-associated immune checkpoint

This paper identifies GD3 as a senescence-associated immune checkpoint that suppresses NK cell-mediated clearance of senescent cells, showing that targeting GD3 can enhance anti-fibrotic effects in a mouse model.

EHD2-mediated restriction of caveolar dynamics regulates cellular lipid uptake

This study shows that EHD2 restricts caveolar dynamics to regulate lipid uptake, with loss of EHD2 leading to increased fat accumulation and obesity in mice.

A novel cell-based sensor detecting the activity of individual basic proprotein convertases

The paper introduces PCific, a cell-based sensor to screen and distinguish inhibitors of individual basic proprotein convertases in mammalian cells.