The intrinsically disordered N-terminus of SUMO1 is an intramolecular inhibitor of SUMO1 interactions
S. M. Richter, F. Jin, T. Ritterhoff, A. Fergin, E. Maurer, A. Frank, M. Daube, A. Hajnal, R. E. Klevit, F. Gräter, A. Flotho, F. Melchior
The paper identifies the intrinsically disordered N-terminus of SUMO1 as an intramolecular inhibitor of SUMO-SIM interactions, revealing a mechanism of disorder-based autoinhibition.
bioRxiv · Jan 4, 2024 · PreprintBiochemistry