A. Frank

The intrinsically disordered N-terminus of SUMO1 is an intramolecular inhibitor of SUMO1 interactions

The paper identifies the intrinsically disordered N-terminus of SUMO1 as an intramolecular inhibitor of SUMO-SIM interactions, revealing a mechanism of disorder-based autoinhibition.

SOS1 inhibition enhances the efficacy of and delays resistance to G12C inhibitors in lung adenocarcinoma

This study shows that SOS1 inhibition with BI-3406 enhances G12C inhibitor efficacy and delays resistance in lung adenocarcinoma by targeting resistance mechanisms and drug-tolerant persister cells.

Discovery of a new activator of Slack potassium channels with robust efficacy in models of histamine-independent and chronic itch

This study identifies compound 6 as a potent Slack potassium channel activator effective in treating histamine-independent and chronic itch without motor side effects.

A novel phenylpropanoid methyl esterase enables catabolism of aromatic compounds that inhibit biological nitrification

The paper identifies a novel phenylpropanoid methyl esterase that catabolizes aromatic biological nitrification inhibitors, enabling their use as carbon sources by bacteria.

Pump-less, recirculating organ-on-a-chip (rOoC) platform

This paper introduces a pump-less organ-on-a-chip platform that enables directional flow through gravity and microfluidic design, demonstrating endothelialisation and hepatic organoid integration.

Differential requirements for mitochondrial electron transport chain components in the adult murine liver

This study investigates the tissue-specific roles of mitochondrial complex I and IV in adult mouse liver, finding that complex I loss is tolerated while complex IV dysfunction causes metabolic and functional impairments.

Reliance on polyfunctional tissue leads to a reproduction-immunity tradeoff due to inherent constraint

The paper shows that in Drosophila, reproductively active females have reduced protein production capacity during infection, leading to a reproduction-immunity tradeoff.

First Crystal Structure of a Non-Structural Hepatitis E Viral Protein Identifies a Putative Novel Zinc-Binding Protein

The paper determines the crystal structure of a non-structural HEV protein, revealing a zinc-binding motif and structural homology to a fatty acid binding domain.

Assessing sustainability in North America’s ecosystems using criticality and information theory

The paper develops a sustainability index using information theory and criticality to analyze ecosystem data from AmeriFlux, finding agreement with land condition data but noting limitations.