F. Jin

Joint tracking of active and passive motion in the mouse visual thalamus during natural behaviour

The paper investigates how neurons in the mouse visual thalamus represent active and passive motion during natural behavior and finds that they can track both types of motion and partially separate them.

Pressorum Sensing: Growth-induced Compression Activates cAMP Signaling in Pseudomonas aeruginosa

This paper introduces pressorum sensing in Pseudomonas aeruginosa, showing mechanical compression triggers cAMP signaling via the Pil-Chp system, leading to increased virulence.

Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia

This study identifies exosomal hemoglobin transfer from non-neuronal cells to neurons under hypoxia as a mechanism to maintain mitochondrial homeostasis and protect against neurological injury.

The segmented flavivirus Alongshan virus reduces mitochondrial mass via degrading STAT2 to suppress innate immune response

Immunomagneto-activated hepatocyte-specific tissue vesicle profiling reveals message diversification from regenerating liver

The paper identifies hepatocyte-derived extracellular vesicles (Hep-EVs) as critical regulators of liver regeneration, showing they promote hepatocyte proliferation through Cdk1 activity and offer therapeutic potential.

Stimulation Effects Mapping for Optimizing Coil Placement for Transcranial Magnetic Stimulation

This paper introduces a framework for optimal TMS coil placement without segmentation or meshing, validated across multiple datasets showing consistent results.

The intrinsically disordered N-terminus of SUMO1 is an intramolecular inhibitor of SUMO1 interactions

The paper identifies the intrinsically disordered N-terminus of SUMO1 as an intramolecular inhibitor of SUMO-SIM interactions, revealing a mechanism of disorder-based autoinhibition.

Structural insights into the orthosteric inhibition of P2X receptors by non-ATP-analog antagonists

The paper determines cryo-EM structures of P2X7 receptor with antagonists and identifies key residues for subtype specificity, aiding in antagonist design.

Brain resident memory T cells rapidly expand and initiate neuroinflammatory responses following CNS injury and viral infection

This study identifies antigen-specific brain-resident memory T cells that expand rapidly after CNS injury or viral infection and induce neuroinflammation and peripheral immune suppression.

Memory in Repetitive Protein-Protein Interaction Series -- in Memory of the Late Professor Robert M. Nerem

The paper analyzes memory effects in repetitive protein-protein interactions using experimental techniques and models, finding short- and intermediate-term memory in TCR-pMHC interactions.

A small-molecule lycorine derivative protects from obesity by targeting Na+/K+-ATPase α3 independent of food intake suppression

The paper identifies HLY72, a small-molecule derivative of lycorine, as an anti-obesity agent that targets Na+/K+-ATPase α3 in the brain, promoting lipolysis and thermogenesis without affecting food intake.

Lysosome Lipid Signaling from the Periphery to Neurons Regulates Longevity

This study identifies a lysosomal lipid signaling pathway from fat to neurons in C. elegans that promotes longevity by regulating neuropeptide signaling.

Spatial profiling of microbial communities by sequential FISH with error-robust encoding

This paper introduces SEER-FISH, a method for spatially profiling microbial communities with high multiplexity and accuracy, demonstrating its ability to quantify taxon abundance and map microbial biogeography.

CCR2-dependent monocyte-derived cells restrict SARS-CoV-2 infection

This study identifies a CCR2-dependent monocyte-derived cell mechanism that restricts SARS-CoV-2 infection and inflammation in the lungs of mice.

Microglia and perivascular macrophages act as antigen presenting cells to promote CD8 T cell infiltration of the brain

This study identifies microglia and perivascular macrophages as antigen-presenting cells that present MHC class I antigens to CD8 T cells, facilitating their infiltration into the brain during viral infection.

Characterization of LC-MS based urine metabolomics in healthy subjects across the life span

This study characterizes urine metabolomics across the lifespan in healthy individuals, identifying age- and gender-specific metabolic patterns and pathway enrichments.

Fluorescence-detection size-exclusion chromatography utilizing nanobody technology for expression screening of membrane proteins

This paper introduces FSEC-Nb, a method using nanobody technology to screen membrane protein expression without GFP fusion, successfully identifying ZAC orthologs and SARS-CoV-2 membrane proteins with high monodispersity.

Cryo-EM structure of the MgtE Mg2+ channel pore domain in Mg2+-free conditions reveals cytoplasmic pore opening

The paper determines the cryo-EM structure of MgtE in Mg2+-free conditions, revealing cytoplasmic pore opening and kink motions in TM2 and TM5 helices.

Tumor-stromal IL1β/ NFκB / ESE3 Signal Axis Drives Pancreatic Cancer Fibrosis, Chemoresistance, Prognosis

This study identifies an IL1β/NFκB/ESE3 signaling axis in pancreatic stellate cells that drives fibrosis, chemoresistance, and poor prognosis in pancreatic cancer.

Severe and multifaceted systemic immunosuppression caused by experimental cancers of the central nervous system requires release of non-steroid soluble mediators

This study identifies non-steroid soluble factors released by CNS cancers and injuries that cause systemic immunosuppression by inducing thymic and splenic involution and reducing MHC class II expression.

Carbon starvation induces the expression of PprB-regulated genes in Pesudomonas aeruginosa

This paper identifies carbon starvation stress as a trigger for the PprB regulon in Pseudomonas aeruginosa, revealing its role in enhancing biofilm adhesion through BapA and CupE.

Conditional silencing of H-2Db class I molecule expression on dendritic cells modulates the protective and pathogenic kinetics of virus-antigen specific CD8 T cell responses during Theiler’s Virus infection

This study shows that CD11c+ antigen-presenting cells are critical for early CD8 T cell responses against TMEV, but not for later responses, using a conditional H-2Db knockout mouse model.

Heterogeneity in surface sensing produces a division of labor in Pseudomonas aeruginosa populations

This study shows that Pseudomonas aeruginosa develops two subpopulations with distinct c-di-GMP levels after surface attachment, leading to a division of labor in biofilm formation and surface exploration.

Proteomic Profile of TGF-β1 treated Lung Fibroblasts identifies Novel Markers of Activated Fibroblasts in the Silica Exposed Rat Lung

The paper identifies 196 differentially expressed proteins in TGF-β1-treated lung fibroblasts and finds that VLDLR and SDC2 are upregulated in silica-exposed lungs, with knockdown reducing collagen production.