F. Gräter

The paper identifies the intrinsically disordered N-terminus of SUMO1 as an intramolecular inhibitor of SUMO-SIM interactions, revealing a mechanism of disorder-based autoinhibition.

This study shows mechanical forces increase VAR2CSA's binding avidity by converting it from monovalent to multivalent through conformational changes exposing additional CSA binding sites.

The paper identifies weak sacrificial bonds in collagen that break first under stress, stabilizing mechanoradicals and preventing macroscopic failure.

This study identifies PDI-mediated cleavage of a disulfide bond in Mac-1 as a mechanism enabling neutrophil directional movement under flow by promoting de-adhesion from ICAM-1.

This study identifies two physical principles governing centriole formation through surface-catalyzed SAS-6 self-assembly and structural conversion.