Alpha-ketoglutarate inhibits Regulatory T cell differentiation by coupling lipidome remodelling to mitochondrial metabolism
M. I. Matias, C. S. Yong, A. Foroushani, E. Sezgin, K. R. Levental, A. Talebi, C. Mongellaz, J. Dehair, M. Wong, S. Kinet, V. S. Zimmermann, I. Levental, L. Yvan-Charvet, J. v. Swinnen, S. Muljo, , N. Taylor
This study shows that alpha-ketoglutarate inhibits regulatory T cell differentiation by altering lipid metabolism and mitochondrial function.
bioRxiv · Aug 24, 2020 · PreprintImmunology