Plasticity and lineage commitment of individual Th1 cells are determined by stable T-bet expression quantities
A. N. Hegazy, C. Peine, D. Niesen, I. Panse, Y. Vainshtein, C. Kommer, Q. Zhang, T. M. Brunner, M. Peine, A. Froehlich, N. Ishaque, R. M. Marek, J. J. Zhu, T. Hoefer, M. Loehning
This study shows that T-bet expression levels in Th1 cells determine their plasticity and lineage stability, with virus-induced interferons regulating these states.
bioRxiv · Aug 14, 2022 · PreprintImmunology