T. Hoefer

Medulloblastoma oncogene aberrations are not involved in tumor initiation, but essential for disease progression and therapy resistance

The paper uses single-cell technologies to show that large-scale chromosomal aberrations drive medulloblastoma initiation, while single-gene oncogenic events like MYC contribute to progression and therapy resistance.

Population context drives cell-to-cell variability in interferon response in epithelial cells

The paper shows that population context affects cell-to-cell variability in interferon response in human intestinal epithelial cells, with edge cells being more responsive than central ones.

Plasticity and lineage commitment of individual Th1 cells are determined by stable T-bet expression quantities

This study shows that T-bet expression levels in Th1 cells determine their plasticity and lineage stability, with virus-induced interferons regulating these states.

High-resolution kinetic gene expression analysis of T helper cell differentiation reveals a STAT-dependent, unique transcriptional program in Th1/2 hybrid cells

This study analyzes the dynamic transcriptome of Th cell differentiation, revealing a unique STAT-dependent transcriptional program in Th1/2 hybrid cells.

DEAD-box RNA Helicases Act as Nucleotide Exchange Factors for Casein Kinase 2

The paper shows DDX proteins act as nucleotide exchange factors for CK22, enhancing kinase activity and revealing a new regulatory mechanism for protein kinases.

MYCN mediates cysteine addiction and sensitizes to ferroptosis

This study shows MYCN promotes cysteine addiction and ferroptosis resistance in neuroblastoma, identifying therapeutic targets for ferroptosis induction.

Single cell multi-omics analysis of chromothriptic medulloblastoma highlights genomic and transcriptomic consequences of genome instability

This study analyzes single-cell multi-omics data from medulloblastoma to explore genomic and transcriptomic impacts of chromothripsis and its subclonal variation.

Asynchronous nuclear cycles in multinucleated Plasmodium falciparum enable rapid proliferation

The paper shows that Plasmodium falciparum nuclei replicate DNA asynchronously, leading to heterogeneous progeny numbers and slower replication during overlapping events.

Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor

The study shows that the half-life of the ligand-T cell receptor complex determines T cell activation, supporting the kinetic proofreading model.