A. Hoffmann

Control of cholesterol-induced adipocyte inflammation by the Nfe2l1-Atf3 pathway

This study identifies the Nfe2l1-Atf3 pathway as a regulator of cholesterol-induced adipocyte inflammation and insulin resistance in both human and mouse models.

Discovery and characterization of unusual O-link glycosylation of IgG4 antibody using LC-MS

The paper identifies and characterizes O-link glycosylation in IgG4 antibodies using LC-MS and mass spectrometry analysis of Dupixent.

The metabolic cofactor Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling

This study shows Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling by providing a weak TLR4 signal.

Tracking of Lineage Mass via Quantitative Phase Imaging and Confinement in Low Refractive Index Microwells

This paper introduces a platform combining quantitative phase imaging and microwell confinement to improve lineage tracking by measuring cell mass.

Vaccination by single dose sporozoite injection of blood stage attenuated malaria parasites

The paper identifies slow-growing, avirulent malaria parasite mutants that protect against disease after challenge with wild-type parasites.

Active smelling in the American cockroach

This study examines how American cockroaches use antennal movements to interact with odors, showing changes in kinematics and increased sweeps during odor exposure.

Differences in gene expression in field populations of Wolbachia-infected Aedes aegypti mosquitoes with varying release histories in northern Australia

This study examines gene expression changes in Wolbachia-infected Aedes aegypti mosquitoes with different release histories, finding persistent immune-related gene upregulation despite reduced gene expression changes over time.

A stimulus-contingent positive feedback loop enables IFN-β dose-dependent activation of pro-inflammatory genes

The paper shows high-dose IFN-β activates a pro-inflammatory gene program through a stimulus-contingent positive feedback loop in ISGF3, unlike IFN-λ3.

Sex-specific distribution and classification of Wolbachia infections and mitochondrial DNA haplogroups in Aedes albopictus from the Indo-Pacific

The paper analyzes genomic data from Aedes albopictus across the Indo-Pacific to classify Wolbachia infections and mitochondrial haplogroups, finding sex-specific infection patterns and no cryptic species.

Virtually the same? Evaluating the effectiveness of remote undergraduate research experiences

This study evaluates remote undergraduate research experiences during the pandemic, finding similar scientific integration outcomes to in-person programs but with differences based on prior experience.

MIF-2/D-DT is an atypical atherogenic chemokine that promotes advanced atherosclerosis and hepatic lipogenesis

This study identifies MIF-2 as an atherogenic chemokine that promotes atherosclerosis and hepatic lipogenesis by acting through CXCR4 and SREBP pathways.

Heterocomplexes between the Atypical Chemokine MIF and the CXC-Motif Chemokine CXCL4L1 Regulate Inflammation and Thrombus Formation

This study identifies a novel interaction between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1, showing that their heterocomplex formation modulates inflammation and thrombus formation.

Reversible brain edema in experimental cerebral malaria is associated with transcellular blood-brain barrier disruption and delayed microhemorrhages

This study identifies transcellular blood-brain barrier disruption as a mechanism for reversible brain swelling in experimental cerebral malaria, with implications for therapeutic strategies.

Factors influencing maternal microchimerism throughout infancy and its impact on infant T cell immunity

The paper examines factors affecting maternal microchimerism (MMc) in infants and its impact on T cell immunity following BCG vaccination.

Characterization of two novel proteins involved in mitochondrial DNA anchoring

This study identifies two novel proteins involved in mitochondrial DNA anchoring in Trypanosoma brucei by combining proteomics and RNAi, showing their localization and essential role in kDNA stability.

Identification and physiological significance of temporal NFκB signaling codewords deployed by macrophages to classify immune threats

This study identifies six temporal NFκB signaling codewords used by macrophages to classify immune threats and shows their role in inflammatory pathology.

A genomic approach to inferring kinship reveals limited intergenerational dispersal in the yellow fever mosquito

The paper uses genomic data to estimate parent-offspring dispersal in yellow fever mosquitoes, finding limited dispersal distances and informing disease control strategies.

Non-heritable variation in individual fitness adds stability to neutral theories in ecology and evolution

The paper shows that non-heritable fitness variation stabilizes coexistence in ecological and evolutionary models without requiring niche differentiation.

Climate, human influence, and the distribution limits of the invasive European earwig, Forficula auricularia, in Australia

The paper models the distribution of the invasive European earwig in Australia, identifying climate and human influence as key factors affecting its range.

A molecular model of the mitochondrial genome segregation machinery in Trypanosoma brucei

The paper uses super-resolution microscopy and biochemical analysis to show the hierarchical assembly of the TAC in Trypanosoma brucei, independent of the mitochondrial genome.

Genome-Wide SNPs Reveal the Drivers of Gene Flow In An Urban Population of the Asian Tiger Mosquito, Aedes albopictus

The paper uses genome-wide SNPs to analyze gene flow in Ae. albopictus, finding that distance from shipping terminals and isolation by distance drive genetic structure.

Addressing the digital divide in contemporary biology: Lessons from teaching UNIX

The paper presents a training model to teach UNIX command-line tools to biomedical researchers with little to no prior knowledge.