An in vitro quantitative systems pharmacology approach for deconvolving mechanisms of drug-induced, multilineage cytopenias
J. Wilson, D. Lu, N. Corr, A. Fullerton, J. Lu
The paper develops a QSP model to predict drug-induced myelosuppression across multiple hematopoietic lineages and validates it with known drug mechanisms.
bioRxiv · Dec 23, 2019Pharmacology & Toxicology