BRD4 Deficiency Selectively Affects a Unique Developmental Subpopulation in Thymocytes
A. Gegonne, Q.-R. Chen, A. Dey, R. Etzensperger, X. Tai, A. Singer, D. Meerzaman, K. Ozato, D. Singer
This study shows BRD4 is critical for T cell development, specifically regulating immature CD8 single-positive thymocytes' progression to double positive thymocytes, while not affecting other stages.
bioRxiv · Jan 10, 2018Immunology