A. Dey

Effects of nano urea on growth and gene expression of Arabidopsis thaliana in hydroponics

This study shows that nano urea enhances biomass and chlorophyll content in Arabidopsis thaliana hydroponics compared to bulk urea, with differential gene expression patterns.

An intricate balancing act: Upstream and downstream frameshift co-regulatory elements

The paper investigates the RNA structures and interactions of the 5' and 3' regions of the SARS-CoV-2 frameshifting element, revealing their co-regulatory roles and implications for therapeutic interventions.

AP2/ERF transcription factors enriched in the drought-response transcriptome of the Thar desert tree Prosopis cineraria show higher copy number and greater DNA-binding affinity than orthologs in drought-sensitive species

This study identifies AP2/ERF transcription factors as key to drought tolerance in Prosopis cineraria, showing higher copy numbers and DNA-binding affinity compared to drought-sensitive species.

Enhanced dynamic covalent chemistry for the controlled release of small molecules and biologics from a nanofibrous peptide hydrogel platform

This study develops SABER hydrogels that extend drug release and therapeutic effect for small molecules and biologics in preclinical models.

Single-molecule Mapping of Amyloid-β Oligomer Insertion intoLipid Bilayers

This study uses QSLIP to map amyloid-beta oligomer membrane insertion, finding toxicity correlates with amino-terminal penetration depth.

50,000 years of Evolutionary History of India: Insights from ~2,700 Whole Genome Sequences

This study analyzes 2,762 whole genome sequences from diverse Indian populations to reconstruct 50,000 years of evolutionary history, revealing major admixture events and archaic hominin gene flow.

Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation

This study identifies RNF146 as an E3 ubiquitin ligase that degrades TEAD proteins via the proteasome, showing that pharmacological induction of TEAD ubiquitination can suppress YAP/TAZ-driven cancer growth.

Mitochondrial dsRNA from B-ALL cells stimulates mesenchymal stromal cells to become cancer associated fibroblasts

This study shows that mitochondrial dsRNA from B-ALL cells triggers MSC to become CAFs, linking genetic subtypes to survival outcomes.

Apolipoprotein-E transforms intracellular Amyloid-β oligomers to a more toxic state

The paper shows ApoE modifies Aβ oligomers to a more toxic form, detectable in live cells, and presents a potential assay for AD drug discovery.

BRD4 directs mitotic cell division by inhibiting DNA damage

This study shows BRD4 is essential for normal cell growth by regulating cell cycle genes and preventing DNA damage during replication and mitosis.

Activation of ERK by altered RNA splicing in cancer

The paper shows that SMNDC1, an upregulated splicing factor in cancer, promotes tumor growth by enhancing ERK1 kinase activity through altered RNA splicing of exon 4.

Structural changes in chromosomes driven by multiple condensin motors during mitosis

The paper develops a computational framework to model loop extrusion by condensin I and II during mitosis, showing changes in loop size and structure across cell types.

RNase H1 exists as phase-separated assemblies in association with elongating RNA Polymerase II during transcription

The paper shows RNase H1 forms phase-separated assemblies with RNA Polymerase II during transcription, regulating R-loop levels through liquid-liquid phase separation.

Microbial induced calcite precipitation can consolidate martian and lunar regolith simulants

This paper shows that microbial induced calcite precipitation can create strong bricks from Martian and lunar regolith simulants using bacteria and additives.

RTK-dependent inducible degradation of mutant PI3K alpha drives GDC-0077 (Inavolisib) efficacy

The paper shows that GDC-0077 and taselisib degrade mutant PI3K alpha via HER2-dependent mechanisms, enhancing efficacy in PIK3CA-mutant breast cancer.

To knot or not to knot: Multiple conformations of the SARS-CoV-2 frameshifting RNA element

The paper identifies multiple structural conformations of the SARS-CoV-2 frameshifting RNA element and their potential roles in viral replication and therapeutic targeting.

Assessment of immunogenicity and protective efficacy of ZyCoV-D DNA vaccine candidates in Rhesus macaques against SARS-CoV-2 infection

This study evaluates two doses of ZyCoV-D DNA vaccine in rhesus macaques, finding that the 2mg dose via Needle Free Injection System provides better immune response and protection against SARS-CoV-2.

Immunogenic Potential of DNA Vaccine candidate, ZyCoV-D against SARS-CoV-2 in Animal Models

This study evaluates the immunogenic potential of the DNA vaccine ZyCoV-D against SARS-CoV-2 in animal models, showing antibody and Th-1 responses.

The kinesin-8 member Kif19 alters microtubule dynamics, suppresses cell adhesion, and promotes cancer cell invasion

This study shows Kif19 promotes cancer cell invasion by altering microtubule dynamics and suppressing cell adhesion.

Receptor-independent membrane mediated pathways of serotonin action

This study shows serotonin can directly modulate membrane properties and cellular processes without acting through receptors.

A Novel Therapeutic Approach to Corneal Alkaline Burn Model by Targeting Fidgetin-like 2, a Microtubule Regulator

This paper evaluates FL2-NPsi, a nanoparticle-encapsulated siRNA targeting FL2, in a rat model of corneal alkaline burn, finding it enhances wound healing without toxicity.

Theory and Simulations of condensin mediated loop extrusion in DNA

The paper develops a theoretical model and simulations to explain condensin-mediated loop extrusion in DNA, showing how ATP binding induces conformational changes that drive loop formation.

BACTERIAL GROWTH INDUCED BIOCEMENTATION TECHNOLOGY, 'SPACE BRICK' - A PROPOSAL FOR EXPERIMENT AT MICROGRAVITY AND PLANETARY ENVIRONMENTS

The paper investigates microbial induced calcite precipitation for manufacturing space bricks and proposes experiments in low-earth orbit using lunar simulant soil.

Studying POU2F1 to Unveil the Structural Facet for Pan-Cancer Analysis Considering the Functional Annotations and Sequence-Structure Space Paradigm

This paper identifies structural facets of POU2F1 critical for stable binding and prevents monomeric aggregation, linking its dynamicity to functional multiplicity in pan-cancer analysis.

Microbially induced calcite precipitation using Bacillus velezensis with guar gum

This study investigates the efficiency of microbially induced calcite precipitation using Bacillus velezensis with guar gum as a biopolymer additive, showing significant precipitation and consolidation of sand.

Sequence variation of rare outer membrane protein β-barrel domains in clinical strains provides insights into the evolution of Treponema pallidum subsp. pallidum, the syphilis spirochete.

The paper analyzes sequence variation in β-barrel domains of OMPs in TPA clinical strains, finding that genetic exchange and host selection pressures drive OMP diversity and inform vaccine strategies.

BRD4 Deficiency Selectively Affects a Unique Developmental Subpopulation in Thymocytes

This study shows BRD4 is critical for T cell development, specifically regulating immature CD8 single-positive thymocytes' progression to double positive thymocytes, while not affecting other stages.