Size-dependent protein segregation creates a spatial switch for Notch signaling and function
M. Kwak, K. M. Southard, N. H. Kim, R. Gopalappa, W. R. Kim, M. An, H. J. Lee, M. K. Kang, S. H. Choi, J. Farlow, A. Georgakopoulos, N. K. Robakis, D. Seo, H. B. Kim, Y. H. Kim, , Y.-w. Jun
The paper shows that spatial constraints at cadherin-based adherens junctions regulate Notch cleavage by gamma-secretase, affecting signaling and cell differentiation.
bioRxiv · Jun 28, 2020Cell Biology