Constitutional activation of BMP4 and WNT signalling in hESC results in impaired mesendoderm differentiation
C. Markouli, E. Couvreu De Deckersberg, D. Dziedzicka, M. Regin, S. Franck, A. Keller, A. Gheldof, M. Geens, K. Sermon, C. Spits
The paper identifies a human embryonic stem cell subline with hyperactivated WNT and BMP4 signaling that impairs mesendoderm differentiation, leading to trophoblast-like cell formation.
bioRxiv · Jun 4, 2020 · PreprintCell Biology