A. Keller

ERK5 Signaling is Required for Type III IFN-mediated Mucosal Antiviral Responses

The paper identifies ERK5 as a potentiator of STAT1 activation and ISG expression, enhancing type III IFN-mediated antiviral responses in epithelial cells.

Perivascular adipose tissue remodeling impairs vasoreactivity in thermoneutral-housed rats

This study shows that thermoneutral housing causes perivascular adipose tissue remodeling in rats, leading to sex-dependent impairments in vasoreactivity and mitochondrial function.

Bumble bee microbiota shows temporal succession and increase of lactic acid bacteria when exposed to outdoor environments

This study shows that bumble bee gut microbiota changes over time when exposed to outdoor environments, with increased diversity and abundance of lactic acid bacteria, but no significant effect from flower diversity.

DNA methylation profiling identifies TBKBP1 as potent amplifier of cytotoxic activity in CMV-specific human CD8+ T cells

The paper identifies TBKBP1 as a key gene whose demethylation enhances cytotoxic activity in CMV-specific CD8+ T cells, suggesting it as a therapeutic target.

Decreased fucosylation impacts epithelial integrity and increases risk for COPD.

This study shows decreased fucosylation impairs epithelial integrity and increases COPD risk by affecting E-cadherin function and cell differentiation.

7,8-Dihydroxyflavone is a direct inhibitor of pyridoxal phosphatase

This study identifies 7,8-dihydroxyflavone as a direct inhibitor of pyridoxal phosphatase, increasing PLP levels in mouse hippocampal neurons and validating PDXP as a druggable target.

Contrasting patterns of foraging behavior in Neotropical stingless bees using pollen and honey metabarcoding

This study uses pollen and honey metabarcoding to analyze foraging behavior in three Neotropical stingless bee species, revealing their floral resource preferences and highlighting forest tree reliance.

Time series of chicken stool metagenomics and egg metabolomics in changing production systems

The paper examines how changing chicken production systems affects gut microbiota and egg metabolites over three weeks, finding significant changes in taxa and metabolomic profiles.

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates

The paper develops AAV vectors with endothelial-specific tropism for brain delivery in rodents and broad tropism in primates, demonstrating their utility in genetic engineering of the blood-brain barrier.

First experimental evidence for active farming in ambrosia beetles and strong heredity of garden microbiomes

The paper experimentally demonstrates that ambrosia beetles actively promote their food fungi and transmit symbionts vertically, showing strong heredity in garden microbiomes.

Thermophoresis of Molecules and Structures of different Sizes in Self-assembled Biomatrices

The paper studies thermophoresis of various biomolecules in self-assembled matrices, showing enhanced thermodiffusion due to surrounding network effects.

Using a combination of CRISPR/Cas9, behavioural experiments and functional analysis to characterise taste receptors in honeybees

The paper identifies the distinct roles of three gustatory receptors in honeybee sugar sensing using CRISPR/Cas9, electrophysiology, and behavior.

Cas9-Mediated Knockout of Ndrg2 Enhances the Regenerative Potential of Dendritic Cells for Wound Healing

This study uses CRISPR/Cas9 to knockout Ndrg2 in dendritic cells, enhancing their regenerative capacity for wound healing in mouse models.

Maternal obesity causes fetal cardiac hypertrophy and alters adult offspring myocardial metabolism in mice

This study shows maternal obesity leads to fetal cardiac hypertrophy and alters adult offspring myocardial metabolism in a sex-dependent manner.

Peptide Scanning of SARS-CoV and SARS-CoV-2 Spike Protein Subunit 1 Reveals Potential Additional Receptor Binding Sites

This paper identifies additional receptor binding sites on SARS-CoV and SARS-CoV-2 spike protein subunit 1 through peptide scanning and validates their ACE2 binding affinity.

Circulating osteopontin released by injured kidneys causes pulmonary inflammation and edema

This study identifies osteopontin (OPN) released by injured kidneys as a mediator of acute lung injury, showing its role in causing pulmonary inflammation and edema.

Bacterial microcompartments for isethionate desulfonation in the taurine-degrading human-gut bacterium Bilophila wadsworthia

This study identifies bacterial microcompartments involved in taurine desulfonation in Bilophila wadsworthia, revealing their role in sulfite respiration and H2S production.

Gains of 12p13.31 delay WNT-mediated initiation of hPSC differentiation and promote residual pluripotency in a cell cycle dependent manner

This study shows that gains of 12p13.31 in hPSC delay WNT signaling and promote residual pluripotency through NANOG and GDF3, dependent on cell cycle position during differentiation.

Xenogeneic Skin Transplantation Promotes Angiogenesis and Tissue Regeneration Through Vitamin D-Activated Trem2+ Macrophages

The paper shows that vitamin D-activated Trem2+ macrophages promote angiogenesis and reduce fibrosis, offering a new strategy for advanced cell therapies in complex wounds.

Environmental DNA Metabarcoding for Simultaneous Monitoring and Ecological Assessment of Many Harmful Algae

This study uses environmental DNA metabarcoding to monitor harmful algae in Hood Canal, finding common presence of harmful taxa and new species, while linking them to ecological conditions.

Endogenous suppression of WNT signalling in human embryonic stem cells leads to low differentiation propensity towards definitive endoderm

The paper shows that endogenous suppression of WNT signaling in hPSCs reduces differentiation efficiency towards definitive endoderm, and that increasing WNT or inhibiting PI3K/AKT can overcome this block.

Constitutional activation of BMP4 and WNT signalling in hESC results in impaired mesendoderm differentiation

The paper identifies a human embryonic stem cell subline with hyperactivated WNT and BMP4 signaling that impairs mesendoderm differentiation, leading to trophoblast-like cell formation.

Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release

This study characterizes and optimizes doxorubicin loading into DNA origami nanostructures, revealing rapid binding and variable release profiles influenced by nanostructure design and environmental factors.

Changes amid constancy: flower and leaf microbiomes along land use gradients and between bioregions

This study examines flower and leaf microbiomes of two plant species across bioregions and land use gradients, finding differences in community structure and responses to environmental factors.

Competitive learning suggests circulating miRNA profiles for cancers decades prior to diagnosis

The paper identifies circulating miRNA profiles associated with cancer decades before diagnosis using competitive learning and serum samples from a large population cohort.

The environmental stress response causes ribosome loss in aneuploid yeast cells.

This study clarifies that aneuploid yeast cells exhibit the environmental stress response (ESR) rather than the CAGE signature, leading to ribosome loss and reduced cellular density.

Sequestration of Methane by Symbiotic Deep-Sea Annelids: Ancient and Future Implications of Redefining the Seep Influence

The paper identifies new deep-sea annelid-bacterial symbioses that actively consume methane, expanding the known spatial extent of methane seeps and their ecological impact.

Differential degradation of RNA species by autophagy related pathways in plants

The paper identifies autophagy-related RNA degradation in plant vacuoles, showing ATG5's role in RNA transport and processing, while vacuolar RNase2 has minimal impact.

FENNEC - Functional Exploration of Natural Networks and Ecological Communities

FENNEC is a tool that automates mapping of ecological trait data to community analyses, enabling easier access to traits like invasiveness and threat status.