CD8 T cells induce destruction of bone marrow stromal niches and hematopoietic stem cell dysfunction in chronic viral infections
S. Isringhausen, L. Kovtonyuk, U. Suessbier, N. Krautler, A. Gomariz, P. M. Helbling, H. Chyn Wong, T. Nagasawa, M. G. Manz, A. Oxenius, C. Nombela-Arrieta
This study shows chronic viral infections impair bone marrow stromal networks and HSC function via CD8 T cell-mediated inflammation.
bioRxiv · May 7, 2020Immunology