An epigenetic memory of inflammation controls context-dependent lineage plasticity in the pancreas
D. J. Falvo, A. Grimont, P. Zumbo, J. L. Yang, A. Osterhoudt, G. Pan, A. F. Rendeiro, J. E. Wilkinson, F. Dündar, O. Elemento, R. K. Yantiss, D. Betel, R. Koche, R. Chandwani
This study shows that inflammation leaves an epigenetic memory in pancreatic acinar cells, affecting their lineage plasticity and tumorigenesis in response to subsequent stress.
bioRxiv · Nov 1, 2021Cancer Biology