G. Pan

Microsporidian Nosema bombycis secretes serine protease inhibitor to suppress host cell apoptosis via caspase BmICE

This paper identifies NbSPN14, a serine protease inhibitor secreted by Nosema bombycis, which inhibits host cell apoptosis by interacting with BmICE, providing insights into pathogen-host interactions.

Enterocytozoon hepatopenaei Proliferate in Procambarus clarkii: A Warning for Crayfish and Shrimp Aquaculture

This study shows that crayfish (Procambarus clarkii) can harbor and transmit the microsporidian parasite Enterocytozoon hepatopenaei, posing a risk to shrimp farming.

A muscle hypertrophy-derived myokine reprograms the stromal vascular fractions differentiation towards thermogenic adipocytes in subcutaneous adipose tissue

This study identifies Thbs4 as a muscle-derived myokine that promotes the conversion of white to beige adipocytes in subcutaneous adipose tissue, improving metabolic health and protecting against high-fat diet-induced disorders.

Microsporidia Ser/Thr Protein Phosphatase PP1 Targets DCs MAPK Pathway and Impairs Immune Functions

This study shows that Microsporidia infection impairs dendritic cell functions by targeting the p38/MAPK pathway via PP1, increasing susceptibility to secondary infections.

Screening of the Pandemic Response Box identifies anti-microsporidia compounds

The paper screens the Pandemic Response Box to identify anti-microsporidia compounds using C. elegans infected with Nematocida parisii, finding four effective inhibitors.

Microsporidia dressing up: the spore polaroplast transport through the polar tube and transformation into the sporoplasm membrane

This study investigates the formation of the sporoplasm membrane during microsporidia spore germination, revealing that the polaroplast transforms into the sporoplasm membrane via the polar tube.

The maize PLASTID TERMINAL OXIDASE (PTOX) gene controls the carotenoid content of kernels.

This study identifies ZmPTOX1 as a key gene for carotenoid biosynthesis in maize kernels, showing that its disruption reduces carotenoid content while overexpression increases it, particularly beta-carotene.

Multimodal electrocorticogram active electrode array based on zinc oxide-thin film transistors

This paper develops a transparent active ECoG array using ZnO-TFTs for electrophysiological monitoring, enabling simultaneous optical and MRI-compatible brain signal recording.

Generating Functional Cells Through Enhanced Interspecies Chimerism with Human Pluripotent Stem Cells

This study demonstrates that MYCN and BCL2 enhance interspecies chimerism with human pluripotent stem cells, enabling the generation of functional human blood progenitor cells in chimeric embryos.

An epigenetic memory of inflammation controls context-dependent lineage plasticity in the pancreas

This study shows that inflammation leaves an epigenetic memory in pancreatic acinar cells, affecting their lineage plasticity and tumorigenesis in response to subsequent stress.

Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes and normal tissues

The paper uses proteomics to compare metabolic pathways across tissues in prediabetes, type 2 diabetes, and normal controls, identifying tissue-specific metabolic dysregulation.

Transferrin receptor (Tfr1) ablation in satellite cells impacts skeletal muscle regeneration through the activation of ferroptosis

Conditional Tfr1 ablation in satellite cells causes ferroptosis, leading to skeletal muscle regeneration defects and labile iron accumulation, recapitulated in aged rodents.

Intra- and inter-individual metabolic profiling highlights carnitine and lysophosphatidylcholine pathways as key molecular defects in type-2 diabetes

The paper identifies metabolic defects in type-2 diabetes by analyzing intra- and inter-individual differences in metabolites across multiple tissues.

Baculovirus utilizes cholesterol transporter Niemann-Pick C1 for host cell entry

This study identifies BmNPC1 as a critical host receptor for baculovirus infection, showing its interaction with the viral glycoprotein gp64 and role in endosomal fusion.