Fine-tuned repression of Drp1 driven mitochondrial fission primes a slow cycling stem/progenitor-like state towards accelerating neoplastic transformation of keratinocytes
K. Mitra, B. M. Spurlock, D. Parker, M. Basu, A. Hjelmeland, S. Gc, S. Liu, G. P. Siegal, A. Gunter, A. Moran
The paper shows that fine-tuned Drp1 repression primes keratinocytes for neoplastic transformation by maintaining a stem/progenitor-like state with elevated stem markers and Cyclin E.
bioRxiv · Mar 5, 2021Cell Biology