S. Liu

SkeleSketch: An Open-Source Tool for Quantifying Microglial Morphology in Fiji/ImageJ

SkeleSketch is an open-source Fiji/ImageJ plugin that automates microglial skeletonization and morphological quantification, showing accuracy across labeling strategies and correlation with commercial software.

Functional Type I and Type II interferon crosstalk restricts progenitor exhausted CD8 T cells through spatial exclusion and checkpoint enforcement

This study identifies a spatially encoded interferon circuit that restricts progenitor exhausted CD8 T cells during chronic infection by enforcing niche sequestration and checkpoint control.

Genomic footprints of domestication in almond (Prunus dulcis)

This study identifies the genomic footprints of almond domestication, revealing multi-regional origins, gene flow from wild relatives, and population-specific selection on stress and agronomic traits.

The Orphan G Protein-Coupled Receptor GPR52 is a Novel Regulator of Breast Cancer Multicellular Organization

This study shows that loss of GPR52 in breast cancer cells increases cell clustering, EMT features, and tumor burden in zebrafish, suggesting GPR52 as a potential therapeutic target.

Wireless, Multimodal Monitoring of Organ Health Using 3D-Printed, Barbed, Bioresorbable Stretchable Microneedle Sensor Arrays

This paper introduces a wireless, 3D-printed microneedle sensor array for multimodal organ monitoring, capable of measuring metabolism, oxygenation, and electrophysiology with spatiotemporal resolution.

Single-Cell and Spatial Transcriptomic Analyses Deciphering the Three-Layer Architecture of Human Tuberculosis Granulomas

This study uses single-cell and spatial transcriptomics to analyze human tuberculosis granulomas, revealing a three-layer structure and identifying potential therapeutic targets.

Structures of Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus virions reveal species-specific tegument and envelope features

This study uses cryoET and deep learning to reveal structural differences in the tegument and envelope of EBV and KSHV virions compared to other herpesviruses.

Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions

This study identifies focal adhesions as the subcellular hubs organizing PI3K-PI(3,4,5)P3-AKT signaling, showing localized lipid production and AKT activation, and demonstrates that combined inhibition of PI3K and FAK enhances cancer cell suppression.

Inhibition of serine racemase prevents diabetic retinopathy

This study shows that inhibiting serine racemase with L-ABH prevents diabetic retinopathy by protecting retinal cells and maintaining glucose homeostasis in diabetic mice.

Polymerization of Tetraspanin 7 into Helical Transmembrane Skeletons for Tubular Membrane Stabilization

The paper identifies TSPAN7's role in forming helical transmembrane structures that stabilize tubular membrane protrusions by sensing curvature and resisting mechanical stress.

Genomic evolution reshapes cell type diversification in the amniote brain

The paper creates a single-cell atlas of amniote brains to study cell type diversification and identifies species-specific gene expression patterns and novel cell subtypes.

Avoidable false PSMC population size peaks occur across numerous studies

The paper identifies and resolves false population size peaks in PSMC analyses, showing they result from parameter settings and not true population dynamics.

Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis

This study identifies ADGRA3 as a GPCR that promotes adipose thermogenesis through constitutive activity and the Gs-PKA-CREB axis, with hesperetin as a potential agonist for therapeutic obesity treatment.

A 20+ Ma old enamel proteome from Canada's High Arctic reveals diversification of Rhinocerotidae in the middle Eocene-Oligocene

This paper retrieves ancient enamel protein sequences from a 21-24 Ma rhinocerotid, providing new phylogenetic insights into Rhinocerotidae diversification during the middle Eocene-Oligocene.

Single-nucleus transcriptomics reveal the cytological mechanism of conjugated linoleic acids in regulating intramuscular fat deposition

This study uses snRNA-seq in pigs to reveal CLAs promote fat infiltration by altering myofiber types and adipocyte differentiation through JNK pathway inhibition.

Brain implantation of tissue-level-soft bioelectronics 1 via embryonic development

This paper introduces a stretchable microelectrode array that integrates into the developing brain, enabling long-term, stable neural activity tracking without disrupting development.

Machine Learning Models for Cardiovascular Disease Prediction: A Comparative Study

This study compares KNN, logistic regression, and random forest for predicting cardiovascular disease using a Kaggle dataset, finding random forest to be the most accurate.

Dynamic Single Cell Transcriptomics Defines Kidney FGF23/KL Bioactivity and Novel Segment-Specific Inflammatory Targets

This study uses single-cell transcriptomics to analyze FGF23 bioactivity and identify novel inflammatory targets in the kidney, revealing interactions between FGF23 and TNF/NF-κB pathways.

Tibetan terrestrial and aquatic ecosystems collapsed with cryosphere loss inferred from sedimentary ancient metagenomics

This paper uses ancient metagenomics and network analysis to show that cryosphere loss over 18,000 years drove ecosystem shifts in the Tibetan Plateau, refuting top-down herbivore control and highlighting keystone plant species.

Targeting PRMT3 Impairs Methylation and Oligomerization of HSP60 to Boost Anti-Tumor Immunity by Activating cGAS/STING Signaling

This study identifies PRMT3 as a driver of immunotherapy resistance in HCC, showing that targeting it enhances anti-tumor immunity via cGAS/STING activation.

Therapeutic potential of SOX9 dysruption in Combined Hepatocellular Carcinoma-Cholangiocarcinoma

This study contrasts the effects of developmental and acute Sox9 deletion in cHCC-CCA models, showing that Sox9 elimination can reduce tumor burden and highlights therapeutic potential.

Cellular and molecular characterization of peripheral glia in the lung and other organs

This study characterizes peripheral glia in the lung and other organs using scRNA-seq, identifying molecularly distinct populations and conserved gene expression across species.

Optimal CXCR5 Expression during Tfh Maturation Involves the Bhlhe40-Pou2af1 Axis

This study identifies the Bhlhe40-Pou2af1 axis as a transcriptional regulator of CXCR5 expression in Tfh cells, independent of the Bcl6-Blimp1 pathway.

Covalent DNA-Encoded Library Workflow Drives Discovery of SARS-CoV-2 Non-structural Proteins Inhibitors

This study uses covalent DNA-encoded libraries to discover inhibitors targeting SARS-CoV-2 proteases 3CLpro and PLpro, identifying novel compounds with potent activity and unique binding modes.

Time-lapse Image Super-resolution Neural Network with Reliable Confidence Quantification for Optical Microscopy

This paper introduces a time-lapse image super-resolution neural network with confidence quantification for optical microscopy, improving temporal consistency and reliability.

Genetic modification of the shikimate pathway to reduce lignin content in switchgrass (Panicum virgatum L.) significantly impacts plant microbiomes

This study examines how genetic modification of the shikimate pathway in switchgrass affects its associated microbiomes, finding altered fungal and bacterial communities in roots, rhizosphere, and leaves.

Selected humanization of yeast U1 snRNP leads to global suppression of pre-mRNA splicing and mitochondrial dysfunction in the budding yeast

The paper humanizes yeast U1 snRNP components to study 5 ss recognition, finding that U1C ZnF substitution causes splicing defects and mitochondrial dysfunction.

SON-dependent nuclear speckle rejuvenation alleviates proteinopathies

This study identifies pyrvinium pamoate as a compound that rejuvenates nuclear speckles, improving protein quality control and reducing YAP1 activity, thereby alleviating proteinopathies in pre-clinical models.

Unlocking TAS2R14 activation through intricate multi-ligand binding networks

The paper presents cryo-EM structures of TAS2R14 with ligands and G proteins, revealing multi-ligand binding sites and activation mechanisms.

Characterization of spike processing and entry mechanisms of seasonal human coronaviruses NL63, 229E and HKU1

This study investigates the entry mechanisms of seasonal human coronaviruses NL63, 229E, and HKU1 using pseudoviruses and cell lines expressing ACE2, APN, or TMPRSS2, revealing endocytosis as the entry route and specific protease and receptor requirements.