M. Basu

Single-cell transcriptomics reveal ddx43+ cells as regulators of slow-cycling neoblasts in planaria

The paper identifies ddx43+ cells as regulators of slow-cycling neoblasts in planaria using single-cell transcriptomics and functional analyses.

Potent neutralization by a receptor binding domain monoclonal antibody with broad specificity for SARS-CoV-2 JN.1 and other variants

This study develops a monoclonal antibody that broadly neutralizes multiple SARS-CoV-2 variants, including JN.1, and shows its protective efficacy in mice.

PLGA-based dual-loaded nanoformulation of DIM and TMZ - An advanced clinical strategy for brain cancer treatment in a combinatorial approach

This study develops a PLGA-based nanoformulation combining TMZ and DIM to enhance GBM treatment by improving drug delivery and synergistic cytotoxic effects.

DDX5 (p68) orchestrates β-catenin, RelA and SP1 mediated MGMT gene expression: Implication in TMZ chemoresistance

This study identifies DDX5 (p68) as a master regulator of MGMT gene expression through interactions with β-catenin, RelA, and SP1, contributing to TMZ chemoresistance in colon cancer.

A novel role of USP7 in imparting partial EMT state in colorectal cancer through the DDX3X-β-catenin axis

This study identifies USP7 as a key regulator of partial EMT in colorectal cancer by stabilizing DDX3X and enhancing Wnt/β-catenin signaling.

E3 Ubiquitin Ligase CHIP Drives Monoubiquitination-mediated Nuclear Import of Tumor Suppressor PTEN

This study identifies CHIP as a novel E3 ubiquitin ligase that monoubiquitinates PTEN, promoting its nuclear import and enhancing its tumor suppressive functions.

The DEAD-box protein p68 and B-catenin: the crucial regulators of FOXM1 gene expression in arbitrating colorectal cancer

This study identifies p68 and β-catenin as regulators of FOXM1 gene expression, showing their role in colorectal cancer progression through promoter activity and oncogenic functions.

Potent universal-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibody

This study identifies a potent universal coronavirus neutralizing monoclonal antibody, 1249A8, effective against multiple variants and demonstrating therapeutic activity through intranasal administration.

Mixed Origins: HIV gp120-specific memory develops from pre-existing memory and naive B cells following vaccination in humans

This study shows that HIV gp120-specific memory B cells arise from both naive and pre-existing cross-reactive memory B cells following vaccination.

Fine-tuned repression of Drp1 driven mitochondrial fission primes a slow cycling stem/progenitor-like state towards accelerating neoplastic transformation of keratinocytes

The paper shows that fine-tuned Drp1 repression primes keratinocytes for neoplastic transformation by maintaining a stem/progenitor-like state with elevated stem markers and Cyclin E.

Therapeutic activity of an inhaled potent SARS-CoV-2 neutralizing human monoclonal antibody in hamsters

This study evaluates an inhaled monoclonal antibody against SARS-CoV-2 in hamsters, showing reduced viral burden and lung pathology with low-dose inhalation.

Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling

The paper shows nitric oxide prevents aortic valve calcification by S-nitrosylating USP9X to activate NOTCH signaling in porcine valve cells and mice.