Clostridioides difficile colonization is not mediated by bile salts and utilizes Stickland fermentation of proline in an in vitro model
X. Huang, A. E. Johnson, J. N. Brehm, T. V. T. Do, T. A. Auchtung, H. C. McCullough, A. I. Lerma, S. J. Haidacher, K. M. Hoch, T. D. Horvath, J. A. Sorg, A. Haag, J. M. Auchtung
This study shows that C. difficile colonization in an in vitro model is not dependent on bile salts but relies on proline fermentation via Stickland pathway, with context-dependent effects.
bioRxiv · Jul 17, 2024 · PreprintMicrobiology