A. Ono

Can Colpoda travel across oceans? Salinity tolerance of resting cysts may enable global dispersal of the species.

The study investigates whether Colpoda cucullus resting cysts can tolerate saline conditions, suggesting a mechanism for oceanic dispersal of freshwater protists.

Temporal Changes in Transcripts of MITE Transposable Elements during Rice Endosperm Development

The paper examines temporal changes in MITE TE transcripts during rice endosperm development and finds dynamic up- and downregulation, with some directionally controlled transcripts.

Toxoplasma gondii subverts the host ESCRT machinery for parasite uptake of host cytosolic proteins

This study identifies TgGRA14 as a parasite protein that recruits the host ESCRT machinery to facilitate uptake of host cytosolic proteins across the parasitophorous vacuole membrane.

Comprehensive analysis of full-length transcripts reveal aberrations of splicing variants in liver cancer

The paper develops a pipeline to analyze full-length transcripts using long-read sequencing and identifies splicing variants and fusion events in liver cancer.

Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture

The paper identifies a mutational mechanism in hepatocellular carcinoma driven by Hepatitis B virus DNA integration, leading to genomic restructuring and oncogenic rearrangements.

The replication of the human respiratory syncytial virus in a T cell line has multiple ineffective steps

This study shows that HRSV infection of CD4+ T cells is inefficient compared to epithelial cells, with reduced fusion, lower protein production, and altered viral trafficking.

Movements of ancient human endogenous retroviruses detected in SOX2-expressing cells

The paper shows SOX2 regulates HERV-K transcription and retrotransposition in stem cells, suggesting a role in embryonic protection while limiting genomic harm.

A Glu-Glu-Tyr sequence in the cytoplasmic tail of the M2 protein renders IAV susceptible to restriction of HA-M2 association in primary human macrophages

This study identifies an M2 protein amino acid motif that enables HA-M2 association in primary human macrophages, revealing a mechanism for MDM-specific restriction of IAV assembly.

A unique small molecule pair controls the plant circadian clock

The paper identifies two small molecules that oppositely regulate the Arabidopsis circadian clock by altering period length, revealing their mode of action through genetic mutants.

Relationships between MA-RNA binding in cells and suppression of HIV-1 Gag mislocalization to intracellular membranes

This study shows that HIV-1 MA-RNA binding suppresses non-specific Gag membrane binding, ensuring PM-specific localization.

Generation of strong casein kinase 1 inhibitor of Arabidopsis thaliana

This study develops a potent CK1 inhibitor, AMI-331, for plant research by optimizing a lead compound through structure-activity relationship studies.

A Defect in Influenza A Virus Particle Assembly Specific to Primary Human Macrophages

This study identifies a defect in Influenza A virus particle assembly in primary human macrophages, specifically in HA-M2 association, which is reversible by disrupting actin polymerization.