A. E. Johnson

Clostridioides difficile colonization is not mediated by bile salts and utilizes Stickland fermentation of proline in an in vitro model

This study shows that C. difficile colonization in an in vitro model is not dependent on bile salts but relies on proline fermentation via Stickland pathway, with context-dependent effects.

Modulatory Effects of IFN-γ and IL-22 on Inflammatory Signaling and Cellular Responses in Intestinal Epithelial Cells

This study investigates how IFN-γ and IL-22 interact in intestinal epithelial cells, showing that their combination can shift IL-22's role from anti-inflammatory to pro-inflammatory.

A familial natural short sleep mutation promotes healthy aging and extends lifespan in Drosophila

This study shows that the dec2P384R mutation in Drosophila extends lifespan and improves health by enhancing mitochondrial function and stress response pathways despite reduced sleep.

Ecological flexibility and selectivity in mixed-species flock participation in birds

The paper examines how avian species balance facilitative and competitive interactions in mixed-species flocks through behavioral flexibility and selectivity.

A small molecule that inhibits the evolution of antibiotic resistance

This paper identifies a small molecule, ARM-1, that inhibits bacterial evolution by targeting Mfd, delaying AMR development across multiple pathogens.

The high-resolution in vivo measurement of replication fork velocity and pausing by lag-time analysis

This paper introduces lag-time analysis to measure replication fork velocity and pausing in vivo, finding locus- and time-dependent dynamics and novel pauses at rDNA.

Reproductive tradeoffs govern sexually dimorphic tubular lysosome induction in C. elegans

The paper shows that male C. elegans induce gut tubular lysosomes on abundant food due to self-imposed dietary restriction, linking cellular changes to sex-specific behavioral priorities in reproduction.

Tubular lysosome induction couples animal starvation to healthy aging

The paper shows that inducing tubular lysosomes through dietary restriction or mTOR inhibition links reduced food intake to lifespan extension in C. elegans.

Relief of the Dma1-mediated checkpoint requires Dma1 autoubiquitination and dynamic localization

This study shows that Dma1's transient removal from SPBs during anaphase B, driven by auto-ubiquitination, is essential for silencing the Dma1-dependent mitotic checkpoint in fission yeast.