Gut bacteria convert cortisol into a distinct hostsignalling molecule
M. Freiberg, T. Wang, R. S. d. L. Rosa, A. Osswald, M. C. R. Melo, D. G. Stouffer, P. S. Buobu, C. Welsh, L. Yang, A. M. Abdel-Hamid, H. L. Doden, S. Devendran, R. M. Pollet, S. Goldberg, L. Ray, , J. M. Ridlon
The paper shows gut bacteria convert cortisol into 20-dihydrocortisol, a distinct host signalling molecule that reprograms colonic transcription and activates inflammatory pathways via NR4A3.
bioRxiv · Jun 12, 2020 · PreprintMicrobiology