Author

H. L. Doden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 2 Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:metagenomics· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. M. Ridlon· 4 shared P. G. Wolf· 3 shared I. Cann· 2 shared K. Anantharaman· 2 shared R. Gaskins· 2 shared S. L. Daniel· 2 shared A. Hamm· 1 shared A. J. Steelman· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersMicrobiology

J. M. Ridlon

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Formation of secondary allo-bile acids by novel enzymes from gut Firmicutes

J. W. L. Lee, E. S. Cowley, P. G. Wolf, H. L. Doden, T. Murai, K. Y. O. Caicedo, L. Ly, F. Sun, H. Takei, H. Nittono, S. L. Daniel, I. Cann, R. Gaskins, K. Anantharaman, J. M. Ridlon

This paper identifies novel enzymes from gut Firmicutes that convert 'kinked' primary bile acids into 'flat' secondary bile acids, with increased abundance in colorectal cancer patients.

bioRxiv · Aug 9, 2022Biochemistry

Fxr signaling and microbial metabolism of bile salts in the zebrafish intestine

J. Wen, G. Padilla Mercado, A. Volland, H. L. Doden, C. R. Lickwar, T. Crooks, G. Kakiyama, C. Kelly, J. L. Cocchiaro, J. M. Ridlon, J. F. Rawls

This study investigates Fxr signaling and microbial bile salt metabolism in zebrafish intestines, revealing conserved pathways and Fxr roles in transcriptional programs.

bioRxiv · Dec 13, 2020Physiology

Completion of the gut microbial epi-bile acid pathway

H. L. Doden, J. M. P. Alves, J. M. Ridlon, P. G. Wolf, H. R. Gaskins, K. Anantharaman

The paper identifies the gene encoding 12{beta}-HSDH, completes the epi-bile acid pathway, and shows its prevalence in the human gut microbiome.

bioRxiv · Sep 27, 2020Microbiology

Gut bacteria convert cortisol into a distinct hostsignalling molecule

M. Freiberg, T. Wang, R. S. d. L. Rosa, A. Osswald, M. C. R. Melo, D. G. Stouffer, P. S. Buobu, C. Welsh, L. Yang, A. M. Abdel-Hamid, H. L. Doden, S. Devendran, R. M. Pollet, S. Goldberg, L. Ray, , J. M. Ridlon

The paper shows gut bacteria convert cortisol into 20-dihydrocortisol, a distinct host signalling molecule that reprograms colonic transcription and activates inflammatory pathways via NR4A3.

bioRxiv · Jun 12, 2020 · PreprintMicrobiology