Global Structure of the Intrinsically Disordered Protein Tau Emerges from its Local Structure
L. S. Stelzl, L. M. Pietrek, A. Holla, J. S. Oroz, M. Sikora, J. Köfinger, B. Schuler, M. Zweckstetter, G. Hummer
This study uses a computational method to model the structural ensemble of tau K18, showing how local structure influences global conformational states and disease-related aggregation.
bioRxiv · Nov 23, 2021Biophysics