B. Schuler

The importance of stereochemistry in the disorder-order continuum of protein-protein interactions

The paper investigates the role of stereochemistry in disordered protein-protein interactions, finding that chirality is inconsequential in fully disordered complexes but essential when folding and binding are coupled.

Single-Molecule FRET at 10 MHz Count Rates

This paper demonstrates a method using DNA nanoantennas to increase photon count rates in smFRET, enabling observation of fast biomolecular dynamics with improved temporal resolution.

A quantitative description for optical mass measurement of single biomolecules

The paper develops a framework for light-based single molecule detection and quantification by simulating mass photometry experiments using Fourier optics and molecular polarizability models.

Ultrafast molecular dynamics observed within a dense protein condensate

The paper studies molecular dynamics in dense protein condensates, finding rapid sub-microsecond reconfiguration despite high viscosity.

Global Structure of the Intrinsically Disordered Protein Tau Emerges from its Local Structure

This study uses a computational method to model the structural ensemble of tau K18, showing how local structure influences global conformational states and disease-related aggregation.

Disordered Proteins Enable Histone Chaperoning on the Nucleosome

The paper shows that disordered regions in proteins like H1 enable competitive displacement by histone chaperones such as prothymosin on the nucleosome.