G. Hummer

The paper identifies three sequential steps by which the ATG12-ATG5-ATG16L1 complex delivers LC3 to the phagophore via WIPI2, ATG16L1, and ATG3.

This study shows that Dictyostelium discoideum uses nuclear pores as conduits for fluid flow during osmotic stress, distinct from passive diffusion and active transport.

The paper visualizes GSDMD nanostructures at the plasma membrane of pyroptotic cells and identifies PI(3,4,5)P3 as a regulator of pore formation.

This study investigates how ALG-2 binds membranes and proteins in a Ca2+-dependent manner, revealing its role in membrane repair and ERES function.

This study maps the structural pathway of class III PI 3-kinase activation by showing how N-myristoylation of VPS15 stabilizes the inactive conformation and how GTP binding promotes activation.

This study identifies FLVCR1 and FLVCR2 as choline and ethanolamine transporters, revealing their structural dynamics and substrate selectivity mechanisms.

This study uses atomistic simulations to reveal the mechanism of directional c-ring rotation in mitochondrial ATP synthase, showing how proton transfer and residue interactions ensure rotation directionality.

This study introduces a method to assemble ssRNA structures using hierarchical chain growth, showing agreement with experimental data and improving accuracy with Bayesian refinement.

This study benchmarks cryo-ET resolution based on lamella thickness and particle depth, showing no negative impact up to 180 nm and ion-induced damage extending 30 nm from surfaces.

This study determines the structure of a bacterial gasdermin pore and reveals a conserved mechanism of pore assembly and membrane targeting.

This study identifies a molecular backdoor mechanism for inorganic phosphate release from actin filaments, showing how a disease-linked mutation alters Pi release rates and filament structure.

The paper investigates how disordered regions in TRPV4 modulate channel activity through lipid-dependent interactions and identifies a conserved autoinhibitory patch that regulates PIP2 binding.

This study uses fluorescence microscopy and modeling to reveal the conformation and dynamics of FG-NUPs within the nuclear pore complex, showing good-solvent conditions facilitate transport.

This study uses atomistic simulations to show that small GSDMDNT oligomers form stable, ion-conducting pores during early pyroptosis, explaining nonselective ion flux without full cell lysis.

The paper introduces TriMem, a parallelized hybrid Monte Carlo simulation tool for lipid membranes, capable of simulating large and curved sub-cellular structures and validating phase diagrams of vesicles.

The paper investigates how the LC3 lipidation machinery interacts with curved membranes during autophagy initiation, showing that ATG12-5-16L1 stabilizes membrane curvature.

This study uses cryo-electron tomography to analyze autophagosome formation in yeast, revealing membrane shape transitions and interactions during biogenesis.

This study reveals the substrate translocation mechanism in P-glycoprotein by determining cryoEM structures and using molecular dynamics simulations to identify conformational changes in TM1 that regulate transport.

The paper identifies CydDC as a heme flippase essential for cytochrome bd maturation, revealing its conformational mechanism through cryo-EM and molecular dynamics.

This study shows that hyperphosphorylation of TDP-43 reduces its phase separation and aggregation, suggesting it may act as a protective mechanism against neurodegeneration.

This study uses a computational method to model the structural ensemble of tau K18, showing how local structure influences global conformational states and disease-related aggregation.

The paper reports cryo-EM structures of AI-2 exporters from E. coli, revealing their pentameric structure and elevator-type transport mechanism.

This study investigates the mechanism of LtaA, a proton-dependent MFS lipid transporter, revealing a trap-and-flip mechanism for lipid translocation.

This study determines cryo-EM structures of ATP13A2 to elucidate its polyamine transport mechanism and structural basis for specificity.

This study uses molecular dynamics simulations to show that the SARS-CoV-2 fusion peptide binds rapidly to host membranes via two amphipathic helices and can withstand mechanical forces up to 250 pN, facilitated by a conserved disulfide bridge.

The paper uses cysteine crosslinking to determine the transmembrane architecture of Ire1 in ER stress signaling, showing an X-shaped configuration independent of stress type.

This study identifies evolutionary innovations in SARS-CoV-2 protein sequences, highlighting functional changes in the spike protein and its furin cleavage site relevant to immune evasion and infection.

The paper uses molecular dynamics simulations to show that FAM134B-RHD clusters drive membrane budding in the ER, influenced by curvature and bilayer asymmetry.

This paper develops a coarse-grained model to simulate FUS protein condensates and maps their phase behavior by adjusting interaction strengths.

The paper identifies SARS-CoV-2 spike epitopes not shielded by glycans using molecular dynamics simulations and epitope mapping.