Author

A. Holt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

C. Martin· 2 shared J. Cahill· 2 shared J. Xiao· 2 shared K. Bettridge· 2 shared R. Moreland· 2 shared R. Young· 2 shared C. O Leary· 1 shared C. O'Leary· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersMicrobiology

C. Martin

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2 papers

Recent·Most cited

Spatial and temporal control of lysis by the lambda holin

J. Cahill, A. Holt, M. Theodore, R. Moreland, C. O Leary, C. Martin, K. Bettridge, J. Xiao, R. Young

The paper investigates the molecular basis of polar lysis in phage λ using time lapse fluorescence microscopy, finding that the holin forms two-dimensional rafts at cell poles before lysis.

bioRxiv · Sep 8, 2023 · PreprintMicrobiology

Phage-encoded cationic antimicrobial peptide used for outer membrane disruption in lysis

A. Holt, J. Cahill, J. Ramsey, C. O'Leary, R. Moreland, C. Martin, D. T. Galbadage, R. Sharan, P. Sule, K. Bettridge, J. Xiao, J. Cirillo, R. Young

This study identifies a phage-encoded cationic antimicrobial peptide, Gp28, that disrupts bacterial outer membranes during lysis, functioning similarly to human antimicrobial peptides like LL-37.

bioRxiv · Jan 8, 2019 · PreprintMicrobiology