R. Sharan

TGFb-ANGPT2-Tie2 axis in cancer-associated fibroblasts reprograms oral cancer cells to embryonic-like cell state with predictive significance of poor prognosis

The paper identifies the TGFβ-ANGPT2-Tie2 axis in cancer-associated fibroblasts that reprograms oral cancer cells to an embryonic-like state, linked to poor prognosis.

Spontaneous differentiation leads to emergence of hybrid cell states relate to poor prognosis in oral cancer

This study identifies dynamic phenotypic states in oral cancer cells and their association with poor prognosis through transcriptomic heterogeneity and drug tolerance.

Proteomic landscape of multi-layered breast cancer internal tumor heterogeneity

This study presents a large-scale proteomic analysis of 330 tumor regions in breast cancer, revealing significant internal proteomic heterogeneity and functional differences between homogeneous and heterogeneous tumors.

Effect of SARS-CoV-2 proteins on vascular permeability

The paper investigates how SARS-CoV-2 proteins affect endothelial cells, identifying specific proteins that induce vascular dysfunction and inflammation.

Evolution of metastases-associated fibroblasts in the lung microenvironment is driven by stage-specific transcriptional plasticity

This study shows lung fibroblasts in breast cancer metastases are transcriptionally dynamic and plastic, with stage-specific gene signatures and Myc as a key regulator linked to poor survival.

SARS-CoV-2 infection leads to acute infection with dynamic cellular and inflammatory flux in the lung that varies across nonhuman primate species

This study compares SARS-CoV-2 infection in three nonhuman primate species, showing varied disease progression and immune responses.

Phage-encoded cationic antimicrobial peptide used for outer membrane disruption in lysis

This study identifies a phage-encoded cationic antimicrobial peptide, Gp28, that disrupts bacterial outer membranes during lysis, functioning similarly to human antimicrobial peptides like LL-37.