Author

A. Isotani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Katsuhara· 1 shared A. Kumanogoh· 1 shared A. Okuda· 1 shared A. Tsuboi· 1 shared E. Ueda· 1 shared F. Fujiki· 1 shared H. Nakajima· 1 shared H. Sugiyama· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperImmunology

A. Katsuhara

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Generating an organ-deficient animal model using a multi-targeted CRISPR-Cas9 system

J. J.-Y. Lim, S. Yuri, T. Kawai, A. Isotani

This study generates organ-deficient embryos using a multi-targeted CRISPR-Cas9 system to enable blastocyst complementation with rat cells, resulting in a thymus in a chimeric mouse.

bioRxiv · Jul 31, 2023Bioengineering

T cell-intrinsic vitamin A metabolism and its signaling are targets for memory T cell-based cancer immunotherapy

F. Fujiki, S. Morimoto, A. Katsuhara, A. Okuda, S. Ogawa, E. Ueda, M. Miyazaki, A. Isotani, M. Ikawa, S. Nishida, H. Nakajima, A. Tsuboi, Y. Oka, J. Nakata, N. Hosen, , H. Sugiyama

This study identifies vitamin A metabolism and its signaling as regulators of memory T cell differentiation and shows their potential as targets for cancer immunotherapy.

bioRxiv · Nov 19, 2021 · PreprintImmunology