S. Morimoto

Establishment of a novel amyotrophic lateral sclerosis patient-derived blood-brain barrier model: Investigating barrier dysfunction and immune cell interaction

This paper establishes a patient-derived blood-brain barrier model using hiPSCs to study BBB dysfunction in ALS and identifies specific TARDBP mutations that do not cause BBB issues.

Screening for novel RyR2 inhibitors by ER Ca2+ monitoring

This study identifies three RyR2 inhibitors using an ER Ca2+ monitoring assay, showing they suppress arrhythmogenic Ca2+ waves without affecting normal Ca2+ transients.

Deep learning for histopathological subtyping and grading of lung adenocarcinoma

This study develops CNNs to subtype and grade lung adenocarcinoma, achieving high accuracy and outperforming most pathologists in grading prediction.

Collaborative workflow between pathologists and deep learning for evaluation of tumor cellularity in lung adenocarcinoma

This paper develops an AI model for tumor cellularity evaluation in lung adenocarcinoma, validated through collaboration with pathologists to improve accuracy.

T cell-intrinsic vitamin A metabolism and its signaling are targets for memory T cell-based cancer immunotherapy

This study identifies vitamin A metabolism and its signaling as regulators of memory T cell differentiation and shows their potential as targets for cancer immunotherapy.

Resident Cardiac Macrophages Mediate Adaptive Myocardial Remodeling

This study identifies CCR2- resident cardiac macrophages as critical for adaptive myocardial remodeling in heart failure, showing their role in ventricular remodeling and coronary angiogenesis.

Estrogen induces mammary ductal dysplasia.

This study shows estrogen can cause mammary ductal dysplasia in a mouse model and demonstrates that isoflavones can inhibit this effect.