Author

A. J. Steyn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. N. Glasgow· 4 shared R. R. Sevalkar· 3 shared J. R. Lancaster· 2 shared K. Lumamba· 2 shared k. Nargan· 2 shared R. L. Hunter· 2 shared S. Nadeem· 2 shared T. Naidoo· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersMicrobiology

J. N. Glasgow

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Detection of Mycobacterium tuberculosis in human tissue via RNA in situ hybridization

k. Nargan, T. Naidoo, M. Msimang, S. Nadeem, G. Wells, R. L. Hunter, A. Hutton, K. Lumamba, J. N. Glasgow, P. V. Benson, A. J. Steyn

This paper uses RNA in situ hybridization to detect Mycobacterium tuberculosis mRNA in human tissue, identifying Mtb in ZN-negative samples and revealing two distinct Mtb populations.

bioRxiv · Oct 4, 2023 · PreprintMicrobiology

Water-soluble tocopherol derivatives inhibit SARS-CoV-2 RNA-dependent RNA polymerase

H. T. Pacl, J. L. Tipper, R. R. Sevalkar, A. Crouse, C. Crowder, UAB Precision Medicine Institute, S. Ahmad, A. Ahmad, G. D. Holder, C. J. Kuhlman, K. C. Chinta, S. Nadeem, T. J. Green, C. M. Petit, A. J. Steyn, , K. S. Harrod

This paper identifies water-soluble tocopherol derivatives as potent inhibitors of SARS-CoV-2 RNA-dependent RNA polymerase, showing synergy with remdesivir.

bioRxiv · Jul 13, 2021 · PreprintMicrobiology

Mycobacterium tuberculosis DosS binds H2S through its Fe3+ heme iron to regulate the Dos dormancy regulon

R. R. Sevalkar, J. N. Glasgow, M. Pettinati, M. A. Martin, V. P. Reddy, S. Basu, E. Alipour, D. B. Kim-Shapiro, D. A. Estrin, J. R. Lancaster, A. J. Steyn

This study shows Mycobacterium tuberculosis uses its DosS sensor kinase to detect H2S via Fe3+ heme binding, activating the dormancy regulon.

bioRxiv · Jun 21, 2021 · PreprintBiochemistry

Mycobacterium tuberculosis H2S functions as a sink to modulate central metabolism, bioenergetics, and drug susceptibility

T. T. R. Kunota, M. A. Rahman, B. E. Truebody, J. S. Mackenzie, V. Saini, D. A. Lamprecht, J. H. Adamson, R. R. Sevalkar, J. R. Lancaster, M. Berney, J. N. Glasgow, A. J. Steyn

This study identifies H2S as an endogenous molecule in M. tuberculosis that modulates metabolism, bioenergetics, and drug susceptibility.

bioRxiv · Jun 2, 2021Microbiology

Host bioenergetic parameters reveal cytotoxicity of anti-tuberculosis drugs undetected using conventional viability assays.

B. M. Cumming, Z. Baig, K. W. Addicott, D. Chen, A. J. Steyn

This study uses extracellular flux analysis to detect anti-tuberculosis drug cytotoxicity in different cell types, revealing effects not captured by conventional viability assays.

bioRxiv · May 6, 2021Pharmacology & Toxicology

3D microarchitecture of the human tuberculous granuloma

G. A. Wells, J. N. Glasgow, K. Nargan, K. Lumamba, R. Madansein, K. Maharaj, R. L. Hunter, T. Naidoo, P. Ramdial, L. Coetzer, S. le Roux, A. du Plessis, A. J. Steyn

This study uses 3D X-ray imaging to reveal complex, branched structures of human tuberculous granulomas, challenging the traditional view of spherical granulomas and suggesting implications for TB treatment strategies.

bioRxiv · Jun 14, 2020 · PreprintMicrobiology