S. Basu

Host-derived CEACAM-laden vesicles engage enterotoxigenic E. coli for elimination and toxin neutralization.

The paper shows that host-derived CEACAM-laden vesicles capture ETEC and its toxins, reducing pathogen load and neutralizing toxins during infection.

KIF2A maintains cytokinesis in mouse embryonic stem cells by stabilising intercellular bridge microtubules

This study identifies KIF2A's role in maintaining cytokinesis in mouse embryonic stem cells by stabilizing intercellular bridge microtubules, which prolongs cytokinesis to support pluripotency.

Unravelling the Dynamics of Bacterial-Laden Respiratory Droplets: Epidemiological Transfer from Fomites to Susceptible Host

This study investigates how respiratory droplets containing Pseudomonas aeruginosa transfer pathogens via surfaces, finding increased viability with mucin and significant transfer at high humidity.

The nucleating agent crystallophore induces instant protein crystallization

This paper demonstrates how the crystallophore TbXo4 accelerates protein crystallization, enabling high-quality crystals for serial crystallography methods.

In-situ serial crystallography facilitates 96-well plate structuralanalysis at low symmetry

This paper introduces an in situ serial crystallography method for analyzing 96-well plates, enabling structure determination of challenging samples at low symmetry.

Co-existence of plasmid-mediated blaNDM-1 and blaNDM-5 in Escherichia coli sequence type 167 and ST101 and their discrimination through restriction digestion

This study identifies and characterizes co-existing blaNDM-1 and blaNDM-5 variants in E. coli isolates using Sanger sequencing and hybrid assembly, and develops a restriction digestion method to distinguish them.

Structural dynamics and functional cooperativity of human NQO1 by ambient temperature serial crystallography and simulations

This study determines the structure of hNQO1 with NADH using serial crystallography and simulations, showing NADH binding stabilizes the protein and drives functional cooperativity through structural communication.

Weather-related changes in the dehydration of respiratory droplets on surfaces bolster bacterial endurance

This study shows that environmental conditions, particularly humidity, significantly affect the survivability of Pseudomonas Aeruginosa in respiratory droplets on surfaces.

Evaporation of bacteria-laden surrogate respiratory fluid droplets: On a hydrophilic substrate versus contact-free environment confers differential bacterial infectivity

This study compares bacterial infectivity in droplet nuclei formed from evaporating respiratory fluid on a hydrophilic substrate versus in a contact-free environment.

Droplet microfluidics for time-resolved serial crystallography

This paper develops a droplet microfluidics approach to produce uniform crystals and enable rapid micromixing for time-resolved serial crystallography.

Non-canonical NF-κB signaling promotes intestinal inflammation by restraining the tolerogenic β-catenin-Raldh2 axis in dendritic cells

Drug-bacterial membrane interactions: A Tale of two force fields

This study compares two force fields for modeling mycolic acid monolayers to assess drug permeability and interaction modes in tuberculosis research.

Klebsiella Pneumoniae turns more virulent under flow stresses in capillary like microchannels

This study shows that Klebsiella pneumoniae becomes more virulent under flow stresses in microchannels, as evidenced by increased proliferation in macrophages.

Molecular pathways and cellular subsets associated with adverse clinical outcomes in overlapping immune-related myocarditis and myositis

The paper uses single-cell RNA sequencing to identify molecular pathways and immune subsets in immune-related myocarditis and myositis, finding clonally expanded CD8+ T cells and specific myeloid cell populations associated with adverse outcomes.

PlexinD1 deficiency in CD11c+ dendritic cells exacerbates airway hyperresponsiveness and enhances IgE and mucus production in allergic asthma

CDK activity at the centrosome regulates the cell cycle

This study shows that the hydrophobic patch mediates cyclin-CDK localization to the centrosome, which is essential for mitotic entry and CDK substrate phosphorylation.

Differential expression of miRNAs between Young-Onset and Late-Onset Indian colorectal carcinoma patients

The paper identifies differentially expressed miRNAs between young-onset and late-onset colorectal carcinoma patients and links them to epithelial-mesenchymal transition and tumor progression.

Optimizing CRE and PhiC31 mediated recombination in Aedes aegypti

This paper improves genetic manipulation techniques in Aedes aegypti by introducing transgenic lines for Cre-mediated recombination and a plasmid-based PhiC31 integrase system for stable transgene integration.

Single-cell Spatial Metabolic and Immune Phenotyping of Head and Neck Cancer Tissues Identifies Tissue Signatures of Response and Resistance to Immunotherapy

This study uses single-cell spatial analysis to identify immune and metabolic tumor microenvironment signatures associated with response and resistance to immunotherapy in head and neck cancer.

Detection of a geminate photoproduct of bovine cytochrome c oxidase by time-resolved serial femtosecond crystallography

The paper detects a geminate photoproduct of bovine cytochrome c oxidase using time-resolved serial femtosecond crystallography, revealing the ligand dissociation trajectory and protein dynamics.

Taxonomic distribution of metabolic functions underpins nutrient cycling in Trichodesmium consortia

The study links microbial taxa and their functional traits to nutrient cycling in Trichodesmium consortia, revealing functional redundancy and interdependencies that enhance resilience in oligotrophic environments.

New Features Surrounding the Cdc42-Ste20 Module that Regulates MAP Kinase Signaling in Yeast

This study identifies new regulatory features of the Cdc42-Ste20 module in yeast MAPK signaling, including Ste20p turnover and a Ste20p-independent pathway branch.

Salmonella Typhimurium effector SseI regulates host peroxisomal dynamics to acquire lysosomal cholesterol for better intracellular growth

The paper shows Salmonella effector SseI recruits peroxisomes to SCVs, activates ARF-1, and facilitates cholesterol transport for bacterial growth.

A Zika virus-responsive sensor-effector system in Aedes aegypti

This paper describes a genetic system in Aedes aegypti mosquitoes that selectively eliminates ZIKV-infected individuals to reduce vectorial capacity.

Ethanolaminephosphate cytidyltransferase is essential for survival, lipid homeostasis and stress tolerance in Leishmania major

This study shows that EPCT is essential for PE synthesis, stress tolerance, and survival in Leishmania major across both promastigote and amastigote stages.

Myeloid-specific KDM6B inhibition sensitizes Glioblastoma to PD1 blockade

This study shows that inhibiting KDM6B in myeloid cells improves response to PD1 blockade in glioblastoma by enhancing anti-tumor immunity.

Partial Activation of PPAR-gamma by Synthesized Quercetin Derivatives Modulates TGF-beta-Induced EMT in Lung Cancer cells

This study shows that partial PPAR-gamma activation by synthesized quercetin derivatives inhibits TGF-beta1-induced EMT and migration in lung cancer cells.

High-resolution temporal profiling of the gut microbiome through the whole life of mice

This study tracks the gut microbiome of mice over their entire lifespan, revealing patterns of microbial persistence and age-related changes linked to longevity.

C-4-Modified Isotetrones Prevent Biofilm Growth and Persister Cell Resuscitation in Mycobacterium smegmatis

This study identifies isotetrone derivatives that inhibit biofilm growth and persister cell formation in M. smegmatis and enhance ciprofloxacin's effectiveness against antibiotic-tolerant cells.

Structural and functional analysis of YopR and identification of an additional key component of the SPβ phage lysis-lysogeny management system

The paper identifies YopR and YosL as key components of the SPβ phage lysis-lysogeny system, showing YopR's DNA-binding role and YosL's necessity for lytic cycle induction.