Targeting IRS-1/2 in uveal melanoma inhibits in vitro cell growth, survival and migration, and in vivo tumor growth.
C. Chattopadhyay, R. Bhattacharya, J. Roszik…·E. A. Grimm
This study shows that NT157, an IRS-1/2 inhibitor, reduces uveal melanoma cell growth, survival, migration, and tumor growth in vivo.