Author

A. Jaffe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

A. Capraro· 3 shared E. Pandzic· 3 shared L. Zhong· 3 shared S. L. Wong· 3 shared N. T. Awatade· 2 shared R. M. Whan· 2 shared S. A. Waters· 2 shared A. Adhikari· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersImmunology

A. Capraro

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Ageing impairs the airway epithelium defence response to SARS-CoV-2

A. Capraro, S. L. Wong, A. Adhikari, K. M. Allan, H. R. Patel, L. Zhong, M. Raftery, A. Jaffe, M. Yeang, A. Aggarwal, L. Wu, E. Pandzic, R. M. Whan, S. Turville, O. Vittorio, , S. A. Waters

This study investigates age-related differences in the nasal epithelium's response to SARS-CoV-2, finding that older adults have impaired host defense and lower viral load due to reduced host machinery expression.

bioRxiv · Apr 5, 2021 · PreprintImmunology

Significant functional differences despite morphological and molecular similarity in fully differentiated matched Conditionally Reprogrammed (CRC) and Feeder free dual SMAD inhibited expanded human nasal epithelial cells

N. T. Awatade, S. L. Wong, E. Pandzic, I. Slapetova, A. Capraro, L. Zhong, N. Turgutoglu, L. K. Fawcett, R. Whan, A. Jaffe, S. Waters

The paper compares functional differences between two culture methods for nasal epithelial cells and finds significant variations in barrier integrity and CFTR-mediated chloride currents despite similar morphology and proteomics.

bioRxiv · May 29, 2020Physiology

Novel antioxidant therapy with the immediate precursor to glutathione, γ-glutamylcysteine (GGC), ameliorates LPS-induced cellular stress in an in vitro cystic fibrosis model

C. K. Hewson, A. Capraro, S. L. Wong, E. Pandzic, B. S. M. Fernando, N. T. Awatade, L. Zhong, G. Hart-Smith, R. M. Whan, S. R. Thomas, A. Jaffe, W. J. Bridge, S. A. Waters

This study shows that γ-glutamylcysteine (GGC) reduces LPS-induced oxidative stress and improves cell viability in a cystic fibrosis model.

bioRxiv · May 27, 2020Cell Biology