L. Wu

Scalable Generation of Clinical-Grade Universal Human cDC1s Enables Potent Antitumor Immunotherapy

This paper develops a scalable method to generate clinical-grade cDC1s from umbilical cord blood, showing improved antitumor efficacy in mouse models and recapitulating DC differentiation.

Dynamic Regulation of Innate Lymphoid Cell Development During Ontogeny

This study investigates the developmental changes in innate lymphoid cell (ILC) subsets using scRNA-seq and differentiation assays, revealing distinct regulatory programs in fetal and adult stages.

Enzymatic access to the rare ΔUA (1->4) Glc 3, 6, N-sulfated heparin disaccharide, implications for heparin quality control

This study characterizes a Bacteroides eggerthii lyase that efficiently cleaves heparin to release a rare anticoagulant disaccharide, offering improved methods for quality control.

Uncovering the hidden RNA virus diversity in Lake Nam Co: evolutionary insights from an extreme high-altitude environment

This study identifies 742 RNA virus species in Lake Nam Co, revealing novel viral groups and evolutionary adaptations in an extreme high-altitude environment.

Large transient assemblies of Apaf1 constitute the apoptosome in cells

The paper shows that Apaf1 forms transient foci during apoptosis, which correspond to the apoptosome and regulate apoptosis progression.

CLCC1 Governs Bilayer Equilibration at the Endoplasmic Reticulum to Maintain Cellular and Systemic Lipid Homeostasis

This study identifies CLCC1 as a key regulator of phospholipid trans-bilayer equilibration at the ER, essential for lipid homeostasis and preventing metabolic diseases.

Single cell profiling of bone metastasis ecosystems from multiple cancer types reveals convergent and divergent mechanisms of bone colonization.

The paper analyzes bone metastases from six cancer types using single-cell RNA-seq to identify three immune archetypes and their mechanisms of bone colonization.

Unbiased metastatic niche-labeling identifies estrogen receptor-positive macrophages as a barrier of T cell infiltration during bone colonization

Epigenetic regulation of alveolar macrophage homeostasis by histone deacetylase 1 and 2

This study shows HDAC1 and HDAC2 are essential for alveolar macrophage homeostasis by suppressing Bim expression and co-regulating differentiation with LSD1.

Interferon-Inducible Guanylate-Binding Protein 5 Inhibits Replication of Multiple Viruses by Binding to the Oligosaccharyltransferase Complex and Inhibiting Glycoprotein Maturation

This paper identifies GBP5 as an ISG that inhibits viral replication by blocking N-glycosylation of viral proteins, including SARS-CoV-2 spike, through interaction with the OST complex.

A Quantitative Metric of Confidence For Segmentation of Nuclei in Large Spatially Variable Image Volumes

The paper introduces a confidence metric for nuclei segmentation in large spatially variable image volumes, showing it correlates with segmentation quality and F1 scores.

Unlocking TAS2R14 activation through intricate multi-ligand binding networks

The paper presents cryo-EM structures of TAS2R14 with ligands and G proteins, revealing multi-ligand binding sites and activation mechanisms.

TAK1-mediated phosphorylation of PLCE1 represses PIP2 hydrolysis to impede esophageal squamous cancer metastasis

This study shows that TAK1 phosphorylates PLCE1 at S1060, reducing PIP2 hydrolysis and inhibiting esophageal squamous cancer metastasis.

Integrative spatial omics reveals distinct tumor-promoting multicellular niches and immunosuppressive mechanisms in Black American and White American patients with TNBC

This study uses spatial omics to identify distinct tumor microenvironment profiles in Black and White American TNBC patients, linking them to different immunosuppressive mechanisms and clinical outcomes.

de Novo Sequencing of Antibodies for Identification of Neutralizing Antibodies in Human Plasma Post SARS-CoV-2 Vaccination

This paper presents a method to sequence polyclonal IgG antibodies from human plasma post-SARS-CoV-2 vaccination, generating recombinant antibodies with neutralizing capabilities.

The transcription factor Zeb2 drives differentiation of age-associated B cells

The paper identifies Zeb2 as a critical transcription factor driving age-associated B-cell differentiation and autoimmunity in humans and mice.

Target-aware Molecule Generation for Drug Design Using a Chemical Language Model

This paper introduces TamGen, a chemical language model for target-aware molecule generation, and shows it produces high-quality compounds with inhibitory activity against Tuberculosis ClpP protease.

coRIC map: a framework for the exploration of multifaceted subcellular RNA-binding proteins

The paper introduces coRIC map, an experimental and analytical framework to study subcellular RNA-binding protein dynamics and interactions, revealing new functions and stress responses.

Non-canonical hepatic androgen receptor mediates glucagon sensitivity in female mice through the PGC1α/ERRα/mitochondria axis

This study identifies hepatic androgen receptor as a mediator of glucagon sensitivity in female mice, revealing its role in glucose and lipid metabolism via the PGC1α/ERRα/mitochondria axis.

Novel hypervariable erythrocyte surface expressed recombinant proteins show promise as serological markers of exposure to Plasmodium falciparum infection.

The paper expresses STEVOR and RIFIN recombinant proteins from Plasmodium falciparum and evaluates their seropositivity in Ugandan cohorts to assess their potential as infection markers.

Efficient inhibition of fusion inhibitor HY3000 peptide to SARS-CoV-2 emerging EG.5, EG.5.1 and BA.2.86 variants

This study evaluates the inhibitory activity of the HY3000 peptide against emerging SARS-CoV-2 variants EG.5, EG.5.1, and BA.2.86, finding it retains potent antiviral effects.

Losartan rewires ovarian cancer tumor-immune microenvironment and suppresses IGF-1 to amplify chemo-immunotherapy sensitivity

This study shows losartan improves chemo-immunotherapy effectiveness in ovarian cancer by altering the tumor microenvironment and reducing IGF-1 signaling in cancer cells.

Structural and mechanistic characterization of bifunctional heparan sulfate N-deacetylase-N-sulfotransferase 1

This study determines the structure of NDST1, revealing its catalytic domains and a non-catalytic N-terminal domain, and proposes a mechanism for its function.

Urban non-point source pollutants cause microbial community homogenization via increasing deterministic processes

This study shows urban non-point source pollutants homogenize microbial communities by increasing deterministic processes and reducing habitat heterogeneity.

Shining Light on Osteoarthritis: Spatially Offset Raman Spectroscopy as a Window into Cartilage Health

This study uses Spatially Offset Raman Spectroscopy (SORS) to non-invasively assess cartilage health and track OA progression by correlating spectroscopic data with mechanical and histological metrics.

A spatially constrained independent component analysis jointly informed by structural and functional network connectivity

This paper introduces sfCICA, a multi-modal ICA model combining structural and functional brain connectivity to estimate ICNs, showing improved modularity and network distinction in schizophrenia.

Large-scale lensless microscopy with fast acquisition and region-wise focusing

This paper develops a fast acquisition and region-wise focusing strategy for lensless microscopy, achieving high-resolution imaging of biological samples with reduced acquisition and reconstruction times.

YfmR is a translation factor that prevents ribosome stalling and cell death in the absence of EF-P

This study identifies YfmR as a translation factor essential for preventing ribosome stalling and cell death in B. subtilis when EF-P is absent.

Tumor-Associated Macrophages Expand Chemoresistant, Ovarian Cancer Stem-Like Cells

This study shows that tumor-associated macrophages (TAMs) enhance ovarian cancer stem-like cell (OvCSC) proliferation and survival, contributing to chemotherapy resistance and relapse.

A framework for Frizzled-G protein coupling and implications to the Wnt-PCP signaling pathways

This study presents cryo-EM structures of FZD6, FZD3, and FZD1 in active and inactive states, revealing a shared activation framework and potential crosstalk between G-protein binding and Wnt-PCP signaling.