Author

O. Vittorio

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:drug response / drug discovery· 2 Assay:imaging· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

D. S. Ziegler· 2 shared F. Saletta· 2 shared T. Shai-Hee· 2 shared A. Adhikari· 1 shared A. Aggarwal· 1 shared A. Capraro· 1 shared A. Care· 1 shared A. Gifford· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

D. S. Ziegler

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

In vivo fate of systemically administered encapsulin protein nanocages and implications for their use in targeted drug delivery

C. Rennie, C. Sives, I. Boyton, D. Diaz, C. A. Gorrie, O. Vittorio, L. Collins-Praino, A. Care

This study investigates the in vivo behavior of encapsulin nanocages in mice, showing their safety, immunogenicity, and clearance via the mononuclear phagocyte system.

bioRxiv · Jul 16, 2023 · PreprintBioengineering

Copper chelation inhibits TGF-β pathways and suppresses epithelial-mesenchymal transition in cancer

E. M. Poursani, D. Mercatelli, P. Raninga, J. L. Bell, F. Saletta, F. V. Kohane, Y. Zheng, J. Rouaen, T. R. Jue, F. T. Michniewicz, E. Kasiou, M. Tsoli, G. Cirillo, S. Waters, T. Shai-Hee, , O. VITTORIO

This paper shows copper chelation inhibits TGF-β pathways and reduces EMT in cancer cells, potentially offering a new therapeutic strategy for targeting TGF-β in cancer.

bioRxiv · Oct 3, 2022 · PreprintCancer Biology

A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer

C. Mayoh, A. Gifford, R. Terry, L. M. Lau, M. Wong, P. Rao, T. Shai-Hee, F. Saletta, D.-A. Khuong-Quang, V. Qin, M. Mateos, D. Meyran, K. E. Miller, A. Yuksel, E. V. Mould, , P. G Ekert

The paper develops a 15-gene immune signature to identify T-cell infiltration in high-risk paediatric cancers, finding up to 31% of such cancers have infiltrating T-cells.

bioRxiv · Sep 16, 2022 · PreprintCancer Biology

GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma

T. Gargett, L. M. Ebert, N. T. H. Truong, P. M. Kollis, K. Sedivakova, W. Yu, E. C. F. Yeo, N. L. Wittwer, B. L. Gliddon, M. N. Tea, R. Ormsby, J. Nowicki, S. Poonnoose, O. Vittorio, D. S. Ziegler, , M. P. Brown

This study demonstrates that GD2-targeting CAR-T cells, enhanced with IL-15 transgene expression, effectively control glioblastoma growth in a preclinical model and are clinically feasible.

bioRxiv · May 1, 2022Immunology

Ageing impairs the airway epithelium defence response to SARS-CoV-2

A. Capraro, S. L. Wong, A. Adhikari, K. M. Allan, H. R. Patel, L. Zhong, M. Raftery, A. Jaffe, M. Yeang, A. Aggarwal, L. Wu, E. Pandzic, R. M. Whan, S. Turville, O. Vittorio, , S. A. Waters

This study investigates age-related differences in the nasal epithelium's response to SARS-CoV-2, finding that older adults have impaired host defense and lower viral load due to reduced host machinery expression.

bioRxiv · Apr 5, 2021 · PreprintImmunology