A. Jensen

Spatial microRNA profiling at single-cell resolution by in situ barcoded extension

The paper introduces miR-Space, a method for spatial miRNA profiling at single-cell resolution, revealing new miRNA distributions and cell-type associations in brain tissues.

In Situ Inference of Copy Number Variations in Image-Based Spatial Transcriptomics

This paper adapts copy number variation inference to image-based spatial transcriptomics data to map malignant clones and tumor microenvironment at single-cell resolution.

Avoidable false PSMC population size peaks occur across numerous studies

The paper identifies and resolves false population size peaks in PSMC analyses, showing they result from parameter settings and not true population dynamics.

Potential Opportunities of Modeling Bioavailability for Monoclonal Antibodies: An Overview of mAbs and the current challenges of mAb development

This paper reviews 10 monoclonal antibodies, analyzes their pharmacokinetic and pharmacodynamic properties, and uses a machine learning model to assess subcutaneous bioavailability and optimize drug delivery.

Breaking the rule: An exceptional Y chromosome introgression between deeply divergent primate species

The paper identifies a Y chromosome introgression between two guenon species, challenging Haldane's rule by showing viable hybridization over six million years.

Large-scale phylogenomics uncovers a complex evolutionary history and extensive ancestral gene flow in an African primate radiation

This study uses whole-genome sequencing of 22 guenon species to show widespread ancient hybridization and gene flow across deeply divergent lineages, with immune-related genes overrepresented in introgressed regions.

A pathogenic fungus uses volatiles to entice male flies into fatal matings with infected female cadavers

The paper shows a fungus uses volatile chemicals to trick male flies into mating with infected female cadavers, enhancing fungal dispersal.

Neutrophils impose strong selective pressure against PfEMP1 variants implicated in cerebral malaria

The paper shows neutrophils kill P. falciparum blood stages via ICAM-1 and PfEMP1 variants linked to cerebral malaria.

G-quadruplex RNA motifs influence gene expression in the malaria parasite Plasmodium falciparum

This study identifies RNA G-quadruplexes in Plasmodium falciparum and shows they influence translation of specific genes, including virulence factors.

Restoration, dispersal and settlement of native European oyster (Ostrea edulis) in energetic tidal areas

The paper models larval dispersal and settlement of European oysters in the Solent, showing that active swimming behavior significantly influences distribution and that refugia in dynamic areas are more effective for restoration.