BiochemistrybioRxiv
Use of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signaling networks using SILAC-based phosphoproteomics
D. P. Byrne, C. J. Clarke, P. Brownridge…·C. E. Eyers
This study uses centrinone and SILAC-based phosphoproteomics to identify PLK4 substrates and reveal a network of PLK4-regulated phosphorylation motifs in human cells.
DOI 10.1042/bcj20200309