Author

A. Kaplan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:chromatin & epigenetic regulation· 4 Assay:DNA methylation· 3 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:CITE-seq· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

H. Khamis· 4 shared S. Rudnizky· 4 shared P. Melamed· 3 shared O. Malik· 2 shared A. Dahal· 1 shared A. E. Kim· 1 shared A. Henn· 1 shared A. Jain· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersBiophysics

H. Khamis

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Communication between DNA and nucleotide binding sites facilitates stepping by the RecBCD helicase

V. Gaydar, R. Zananiri, O. Dvir, A. Kaplan, A. Henn

This study investigates how RecBCD helicase switches between binding states during DNA translocation, revealing coupling between DNA and nucleotide binding that facilitates its processive movement.

bioRxiv · May 22, 2023Biochemistry

Microenvironmental correlates of immune checkpoint inhibitor response in human melanoma brain metastases revealed by T cell receptor and single-cell RNA sequencing

C. A. Alvarez-Breckenridge, S. C. Markson, J. H. Stocking, N. Nayyar, M. Lastrapes, M. R. Strickland, A. E. Kim, M. de Sauvage, A. Dahal, J. M. Larson, J. L. Mora, A. W. Navia, B. M. Kuter, C. M. Gill, M. S. Bertalan, , Bra

bioRxiv · Aug 25, 2021Cancer Biology

Single molecule characterization of the binding kinetics of a transcription factor and its modulation by DNA sequence and methylation

H. Khamis, S. Rudnizky, P. Melamed, A. Kaplan

This paper introduces a single-molecule assay to measure transcription factor binding kinetics and shows how DNA sequence and methylation modulate these interactions.

bioRxiv · May 19, 2021Biophysics

Extended and dynamic linker histone-DNA interactions control chromatosome compaction

S. Rudnizky, H. Khamis, Y. Ginosar, E. Goren, P. Melamed, A. Kaplan

This study reveals extended and dynamic linker histone-DNA interactions that control chromatosome compaction through single-molecule unzipping experiments.

bioRxiv · Oct 10, 2020Biophysics

Single-molecule DNA unzipping reveals asymmetric modulation of a transcription factor by its binding site sequence and context

S. Rudnizky, H. Khamis, O. Malik, A. Squires, A. Meller, P. Melamed, A. Kaplan

This study uses single-molecule DNA unzipping to show how Egr-1's binding affinity and structure are modulated by its binding site sequence and flanking context, with ZF3 showing stronger effects.

bioRxiv · Nov 30, 2017Biophysics

The mechano-chemistry of a monomeric reverse transcriptase

O. Malik, H. Khamis, S. Rudnizky, A. Kaplan

This study uses optical tweezers to show that reverse transcriptase functions as a Brownian ratchet and can polymerize on structured templates by exploiting thermal breathing.

bioRxiv · Oct 31, 2017Biophysics