A. Jain

Sequence programmable nucleic acid coacervates

This study creates programmable DNA and RNA liquids that can be tuned by sequence-specific hybridization to control their material properties.

Characterizing Excretory-Secretory Products Proteome Across Larval Development Stages in Ascaris suum

This study characterizes the excretory-secretory proteome of Ascaris suum larvae across developmental stages to identify potential therapeutic targets for ascariasis prevention.

Tackling Anticancer Drug Resistance and Endosomal Escape in Aggressive Brain Tumors Using Bioelectronics

This study shows that alternating current can enhance drug delivery and overcome resistance in brain tumors by modulating intracellular trafficking.

Development and Initial Characterization of Pigs with DNAI1 Mutations and Primary Ciliary Dyskinesia

This paper develops a PCD pig model with DNAI1 mutations and characterizes its respiratory and sinus disease features, showing similarities to human PCD.

Oncogenic Ras-driven Dorsal/NF-κB signaling contributes to tumorigenesis in a Drosophila carcinoma model

This study shows that oncogenic RasV12 activates Dorsal/NF-κB signaling, promoting tumor growth and malignancy in Drosophila melanogaster tumors.

Regulation of angiogenesis by endocytic trafficking mediated by cytoplasmic dynein 1 light intermediate chain 1

This study shows that LIC1 and RILPL1/2 restrict angiogenesis by promoting VEGFR2 degradation, and their disruption increases angiogenesis through enhanced Rab11-mediated recycling.

Innate floral object identification in the generalist solitary hoverfly pollinator Eristalinus aeneus

This study shows how the hoverfly Eristalinus aeneus uses innate integration of olfactory and visual cues to identify multiple floral species without prior experience.

FLUAV RAM-IGIP: A modified live influenza virus vaccine that enhances humoral and mucosal responses against influenza

This paper develops a modified live influenza virus vaccine (RAM-IGIP) that enhances humoral and mucosal immunity against influenza, showing complete protection in mice.

Targeting PKC alleviates iron overload in diabetes and hemochromatosis

This study shows PKC inhibition reduces iron overload in diabetes and hemochromatosis by modulating ferroportin expression and trafficking.

GOT1 primes the cellular response to hypoxia by supporting glycolysis and HIF1α stabilisation

This study identifies GOT1 as a key factor in priming cells for hypoxic adaptation by enhancing glycolysis and HIF1α stabilization before full HIF1 activation.

Assessing the global prevalence of wild birds in trade

This paper quantifies global bird trade prevalence using seven datasets, identifying species at risk and informing conservation strategies.

Dearth of smoking-induced mutations in NSRO-driven non-small-cell lung cancer despite smoking exposure

The paper examines genomic and transcriptomic changes in NSRO-driven NSCLCs in smokers and non-smokers, finding no smoking-induced mutations but higher transcriptomic cell cycle activity in smokers.

Mild ER Stress Impedes Regulated Secretion By Governing Key Exocytotic and granulogenic Molecular Switches

The paper shows ER stress impairs DCV exocytosis in neuroendocrine cells by reducing key exocytotic and granulogenic switches via the CREB/ATF4/eIF2 axis.

Long-term evolution of proliferating cells using the eVOLVER platform

The paper upgrades the eVOLVER platform to enable long-term, automated experimental evolution of proliferating cells with improved methodology, hardware, and software.

Wireless Electrical-Molecular Quantum Signalling for Cancer Cell Induced Death

This paper demonstrates wireless electrical-molecular quantum signalling using bio-nanoantennae to induce apoptosis in cancer cells through quantum biological tunnelling.

Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations

This study identifies suppressed ferroptosis in male colorectal cancer patients with KRAS mutations, linking it to poorer survival outcomes.

Regulation of Ebola GP conformation and membrane binding by the chemical environment of the late endosome

This study investigates how acidic pH, Ca2+, and anionic phospholipids in the late endosome regulate Ebola GP conformation and membrane binding, revealing key residues and mechanisms involved in virus entry.

Evaluation of the morphological and biological functions of vascularized microphysiological systems with supervised machine learning

The paper evaluates vascularized microphysiological systems using machine learning to predict oxygen transport function from morphological data.

AngioMT: An in silico platform for digital sensing of oxygen transport through heterogenous microvascular networks

AngioMT predicts oxygen distribution in microvascular networks using finite element methods, correlating with experimental results and providing insights into tissue oxygenation.

Steroid hormone imbalance drives macrophage infiltration and Spp1/osteopontin+ foam cell differentiation in the prostate

This study shows that steroid hormone imbalance in mice increases macrophage infiltration and Spp1/osteopontin+ foam cell differentiation in the prostate, with OPN knockout reducing these effects.

Electric Field Responsive Nanotransducers for Glioblastoma

This paper investigates the use of gold, silica oxide, and zinc oxide nanoparticles to enhance the anticancer effects of electric fields on glioblastoma cells.

hERG1 channel subunit composition mediates proton inhibition of IKr in hiPSC CMs

This study shows that changes in hERG1a/1b subunit abundance in hiPSC-CMs affect IKr sensitivity to protons, with mature cells showing reduced inhibition.

KCNH2 encodes a nuclear-targeted polypeptide that mediates hERG1 channel gating and expression

This study identifies a nuclear-targeted hERG1 polypeptide, hERG1NP, encoded by KCNH2, which modulates hERG1 channel function during cardiac development.

The cynosure of CtBP: evolution of a bilaterian transcriptional corepressor

This study investigates the evolution of the CtBP transcriptional corepressor, showing its bilaterian origin, conserved CTD structure, and lineage-specific variations through alternative splicing and gene duplication.

Allosteric inactivation of an engineered optogenetic GTPase

This paper uses NMR spectroscopy to study how light-induced allosteric changes in the Cdc42Lov fusion protein inhibit GTPase signaling, revealing structural and dynamic mechanisms of optogenetic control.

Structural basis of Omicron immune evasion: A comparative computational study of Spike protein-Antibody interaction.

This study uses computational methods to analyze how mutations in the Spike protein of Delta and Omicron variants affect antibody binding affinity and neutralization potential.

Modulation of the extracellular matrix by Streptococcus gallolyticus subsp. gallolyticus and importance in cell proliferation

This study shows Streptococcus gallolyticus subsp. gallolyticus upregulates collagen expression in CRC cells, which mediates its ability to promote cell proliferation and tumor growth.

Evidence for quinol oxidase activity of ImoA, a novel NapC/NirT family protein from the neutrophilic Fe(II) oxidizing bacterium Sideroxydans lithotrophicus ES-1

This study characterizes ImoA, a NapC/NirT family cytochrome from Sideroxydans lithotrophicus ES-1, showing it functions as a quinol oxidase and can replace CymA in electron transfer.

Gene expression based inference of drug resistance in cancer

This study uses gene expression data and machine learning to predict drug resistance in cancer by analyzing pathway activity patterns rather than gene expression levels alone.

Nuclear-injuries by aberrant dynein-forces defeat proteostatic purposes of Lewy Body Inclusions

This study investigates how Lewy Bodies (LBs) and Syn-aggresomes interact in neurons, showing LBs overgrow and cause proteostatic issues through lamina injuries and dynein-force imbalances.